Cardiovascular Complications of Imipramine Intoxication

Michael H. Sacks; Richard J. Bonforte; Richard P. Lasser; Ivan Dimich

doi:10.1001/jama.1968.03140340058018

Cardiovascular Complications of Imipramine Intoxication

Michael H. Sacks
, Richard J. Bonforte
, Richard P. Lasser
, Ivan Dimich

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

A 2 1/2-year-old boy died as a result of cardiovascular complications of imipramine hydrochloride overdosage. Through a direct toxic effect on the myocardium, imipramine lowers myocardial contractility and cardiac output with resultant hypotension. Cardiac arrhythmias are also a constant feature of imipramine toxicity. Since there is no specific antidote to imipramine, treatment of over-dosage with this drug must be directed at its life-threatening circulatory and respiratory manifestations if the patient is to stand any chance for survival.

Original language	English
Pages (from-to)	588-590
Number of pages	3
Journal	JAMA - Journal of the American Medical Association
Volume	205
Issue number	8
DOIs	https://doi.org/10.1001/jama.1968.03140340058018
State	Published - 19 Aug 1968

Access to Document

10.1001/jama.1968.03140340058018

Cite this

@article{45cc0f920282406ba261e1069abd5836,

title = "Cardiovascular Complications of Imipramine Intoxication",

abstract = "A 2 1/2-year-old boy died as a result of cardiovascular complications of imipramine hydrochloride overdosage. Through a direct toxic effect on the myocardium, imipramine lowers myocardial contractility and cardiac output with resultant hypotension. Cardiac arrhythmias are also a constant feature of imipramine toxicity. Since there is no specific antidote to imipramine, treatment of over-dosage with this drug must be directed at its life-threatening circulatory and respiratory manifestations if the patient is to stand any chance for survival.",

author = "Sacks, \{Michael H.\} and Bonforte, \{Richard J.\} and Lasser, \{Richard P.\} and Ivan Dimich",

year = "1968",

month = aug,

day = "19",

doi = "10.1001/jama.1968.03140340058018",

language = "English",

volume = "205",

pages = "588--590",

journal = "JAMA - Journal of the American Medical Association",

issn = "0098-7484",

publisher = "American Medical Association",

number = "8",

}

TY - JOUR

T1 - Cardiovascular Complications of Imipramine Intoxication

AU - Sacks, Michael H.

AU - Bonforte, Richard J.

AU - Lasser, Richard P.

AU - Dimich, Ivan

PY - 1968/8/19

Y1 - 1968/8/19

N2 - A 2 1/2-year-old boy died as a result of cardiovascular complications of imipramine hydrochloride overdosage. Through a direct toxic effect on the myocardium, imipramine lowers myocardial contractility and cardiac output with resultant hypotension. Cardiac arrhythmias are also a constant feature of imipramine toxicity. Since there is no specific antidote to imipramine, treatment of over-dosage with this drug must be directed at its life-threatening circulatory and respiratory manifestations if the patient is to stand any chance for survival.

AB - A 2 1/2-year-old boy died as a result of cardiovascular complications of imipramine hydrochloride overdosage. Through a direct toxic effect on the myocardium, imipramine lowers myocardial contractility and cardiac output with resultant hypotension. Cardiac arrhythmias are also a constant feature of imipramine toxicity. Since there is no specific antidote to imipramine, treatment of over-dosage with this drug must be directed at its life-threatening circulatory and respiratory manifestations if the patient is to stand any chance for survival.

UR - https://www.scopus.com/pages/publications/0014422986

U2 - 10.1001/jama.1968.03140340058018

DO - 10.1001/jama.1968.03140340058018

M3 - Article

C2 - 5695005

AN - SCOPUS:0014422986

SN - 0098-7484

VL - 205

SP - 588

EP - 590

JO - JAMA - Journal of the American Medical Association

JF - JAMA - Journal of the American Medical Association

IS - 8

ER -

Cardiovascular Complications of Imipramine Intoxication

Abstract

Access to Document

Fingerprint

Cite this