Cardiovascular complications of diabetes mellitus: The Tissue Factor perspective

Vladimir Y. Bogdanov, Bjarne Østerud

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

Heightened activity of circulating Tissue Factor (TF) has been linked to a variety of macro- and microvascular cardiovascular complications commonly observed in diabetes mellitus. Systemic and localized vascular abnormalities comprise the most debilitating feature of diabetic pathophysiology. Blood monocytes are chronically activated in diabetes, and serve as the major source of bioactive intravascular TF. This review examines recent literature on this subject, with a special emphasis on the abnormal monocyte physiology in diabetes and the structural and functional diversity of circulating TF.

Original languageEnglish
Pages (from-to)112-118
Number of pages7
JournalThrombosis Research
Volume125
Issue number2
DOIs
StatePublished - Feb 2010
Externally publishedYes

Keywords

  • Tissue Factor
  • cardiovascular complications
  • diabetes

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