Cardiotoxic properties of cocaine: studies with positron emission tomography.

N. D. Volkow; J. S. Fowler; Y. S. Ding

Cardiotoxic properties of cocaine: studies with positron emission tomography.

N. D. Volkow
, J. S. Fowler
, Y. S. Ding

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

This study documented marked accumulation of cocaine in the human and baboon heart, which was not inhibited by desipramine pretreatment. However, cocaine inhibited 6-[18F]fluoronorepinephrine uptake in heart to the same degree as did desipramine (Fowler et al. 1994). Since uptake of [18F]norepinephrine in the heart is a function of its uptake by the NE transporter (Fowler et al. 1994), its inhibition by cocaine corroborates in vivo a significant interaction of cocaine with this transporter.

Original language	English
Pages (from-to)	159-174
Number of pages	16
Journal	NIDA Research Monograph Series
Volume	163
State	Published - 1996
Externally published	Yes

Cite this

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title = "Cardiotoxic properties of cocaine: studies with positron emission tomography.",

abstract = "This study documented marked accumulation of cocaine in the human and baboon heart, which was not inhibited by desipramine pretreatment. However, cocaine inhibited 6-[18F]fluoronorepinephrine uptake in heart to the same degree as did desipramine (Fowler et al. 1994). Since uptake of [18F]norepinephrine in the heart is a function of its uptake by the NE transporter (Fowler et al. 1994), its inhibition by cocaine corroborates in vivo a significant interaction of cocaine with this transporter.",

author = "Volkow, \{N. D.\} and Fowler, \{J. S.\} and Ding, \{Y. S.\}",

year = "1996",

language = "English",

volume = "163",

pages = "159--174",

journal = "NIDA Research Monograph Series",

issn = "1046-9516",

publisher = "National Institute on Drug Abuse",

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T1 - Cardiotoxic properties of cocaine

T2 - studies with positron emission tomography.

AU - Volkow, N. D.

AU - Fowler, J. S.

AU - Ding, Y. S.

PY - 1996

Y1 - 1996

N2 - This study documented marked accumulation of cocaine in the human and baboon heart, which was not inhibited by desipramine pretreatment. However, cocaine inhibited 6-[18F]fluoronorepinephrine uptake in heart to the same degree as did desipramine (Fowler et al. 1994). Since uptake of [18F]norepinephrine in the heart is a function of its uptake by the NE transporter (Fowler et al. 1994), its inhibition by cocaine corroborates in vivo a significant interaction of cocaine with this transporter.

AB - This study documented marked accumulation of cocaine in the human and baboon heart, which was not inhibited by desipramine pretreatment. However, cocaine inhibited 6-[18F]fluoronorepinephrine uptake in heart to the same degree as did desipramine (Fowler et al. 1994). Since uptake of [18F]norepinephrine in the heart is a function of its uptake by the NE transporter (Fowler et al. 1994), its inhibition by cocaine corroborates in vivo a significant interaction of cocaine with this transporter.

UR - https://www.scopus.com/pages/publications/0029679630

M3 - Article

C2 - 8809858

AN - SCOPUS:0029679630

SN - 1046-9516

VL - 163

SP - 159

EP - 174

JO - NIDA Research Monograph Series

JF - NIDA Research Monograph Series

ER -

Cardiotoxic properties of cocaine: studies with positron emission tomography.

Abstract

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