Cardiotoxic properties of cocaine: studies with positron emission tomography.

N. D. Volkow, J. S. Fowler, Y. S. Ding

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

This study documented marked accumulation of cocaine in the human and baboon heart, which was not inhibited by desipramine pretreatment. However, cocaine inhibited 6-[18F]fluoronorepinephrine uptake in heart to the same degree as did desipramine (Fowler et al. 1994). Since uptake of [18F]norepinephrine in the heart is a function of its uptake by the NE transporter (Fowler et al. 1994), its inhibition by cocaine corroborates in vivo a significant interaction of cocaine with this transporter.

Original languageEnglish
Pages (from-to)159-174
Number of pages16
JournalNIDA Research Monograph Series
Volume163
StatePublished - 1996
Externally publishedYes

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