@article{b657a0c4a1f34dee8ec982deeb03397d,
title = "Cardiometabolic-Based Chronic Disease, Addressing Knowledge and Clinical Practice Gaps: JACC State-of-the-Art Review",
abstract = "In the second part of this JACC State-of-the-Art Review, an early and sustainable preventive care plan is described for cardiometabolic-based chronic disease. This plan can improve cardiometabolic health by targeting early mechanistic events to decrease the risk for certain cardiovascular diseases (e.g., coronary heart disease, heart failure, and atrial fibrillation). Included are various prevention modalities, intensive lifestyle interventions, pharmacotherapy and cardiovascular outcome trial evidence, and bariatric/metabolic procedures. A tactical approach of implementing published clinical practice guidelines/algorithms for early behavioral, adiposity, and dysglycemia targeting is emphasized, as well as relevant educational and research implications.",
keywords = "adipokines, adiposity, atherosclerosis, atrial fibrillation, cardiometabolic, cardiomyopathy, cardiovascular, chronic disease, dysglycemia, health, insulin, obesity, resistance, type 2 diabetes",
author = "Mechanick, {Jeffrey I.} and Farkouh, {Michael E.} and Newman, {Jonathan D.} and Garvey, {W. Timothy}",
note = "Funding Information: Dr. Mechanick has received honoraria from Abbott Nutrition International. Dr. Farkouh has received research grants from Amgen, Novartis, and Novo Nordisk. Dr. Newman has received research grants from the National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (K23HL125991); and has received honoraria from Creative Educational Concepts. Dr. Garvey has served on ad hoc advisory boards for Sanofi, Novo Nordisk, Boehringer Ingelheim, Gilead, Amgen, BOYDSense, and the American Medical Group Association; and has conducted research sponsored by the University of Alabama at Birmingham funded by Sanofi, Merck/Pfizer, Novo Nordisk, AstraZeneca, and Lexicon. Funding Information: Dr. Mechanick has received honoraria from Abbott Nutrition International. Dr. Farkouh has received research grants from Amgen, Novartis, and Novo Nordisk. Dr. Newman has received research grants from the National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (K23HL125991); and has received honoraria from Creative Educational Concepts. Dr. Garvey has served on ad hoc advisory boards for Sanofi, Novo Nordisk, Boehringer Ingelheim, Gilead, Amgen, BOYDSense, and the American Medical Group Association; and has conducted research sponsored by the University of Alabama at Birmingham funded by Sanofi, Merck/Pfizer, Novo Nordisk, AstraZeneca, and Lexicon. Publisher Copyright: {\textcopyright} 2020 American College of Cardiology Foundation",
year = "2020",
month = feb,
day = "11",
doi = "10.1016/j.jacc.2019.11.046",
language = "English",
volume = "75",
pages = "539--555",
journal = "Journal of the American College of Cardiology",
issn = "0735-1097",
publisher = "Elsevier USA",
number = "5",
}