Cardiac sympathetic denervation in Ross syndrome demonstrated by MIBG-SPECT

Katrin Druschky; Max Joseph Hilz; Christof Koelsch; Günther Platsch; Bernhard Neundoerfer

doi:10.1016/S0165-1838(99)00018-1

Cardiac sympathetic denervation in Ross syndrome demonstrated by MIBG-SPECT

Katrin Druschky, Max Joseph Hilz, Christof Koelsch, Günther Platsch, Bernhard Neundoerfer

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

We investigated cardiac sympathetic innervation by metaiodobenzylguanidine (MIBG) imaging in a patient with tonic pupils, loss of tendon reflexes, and segmental anhidrosis (Ross syndrome). Despite normal cardiovascular reflex tests, we observed a reduced global myocardial MIBG uptake as well as a regional uptake defect over the posterolateral cardiac territory indicating left ventricular peripheral sympathetic denervation. MIBG imaging seems to be a useful noninvasive diagnostic method for detection of early - possibly subclinical - cardiac autonomic impairment in Ross syndrome and provides further evidence of injury to postganglionic autonomic neurons as the underlying pathological mechanism of the disease.

Original language	English
Pages (from-to)	184-187
Number of pages	4
Journal	Journal of the Autonomic Nervous System
Volume	76
Issue number	2-3
DOIs	https://doi.org/10.1016/S0165-1838(99)00018-1
State	Published - 28 May 1999
Externally published	Yes

Keywords

Cardiac sympathetic denervation
MIBG imaging
Ross syndrome

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title = "Cardiac sympathetic denervation in Ross syndrome demonstrated by MIBG-SPECT",

abstract = "We investigated cardiac sympathetic innervation by metaiodobenzylguanidine (MIBG) imaging in a patient with tonic pupils, loss of tendon reflexes, and segmental anhidrosis (Ross syndrome). Despite normal cardiovascular reflex tests, we observed a reduced global myocardial MIBG uptake as well as a regional uptake defect over the posterolateral cardiac territory indicating left ventricular peripheral sympathetic denervation. MIBG imaging seems to be a useful noninvasive diagnostic method for detection of early - possibly subclinical - cardiac autonomic impairment in Ross syndrome and provides further evidence of injury to postganglionic autonomic neurons as the underlying pathological mechanism of the disease.",

keywords = "Cardiac sympathetic denervation, MIBG imaging, Ross syndrome",

author = "Katrin Druschky and Hilz, \{Max Joseph\} and Christof Koelsch and G{\"u}nther Platsch and Bernhard Neundoerfer",

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T1 - Cardiac sympathetic denervation in Ross syndrome demonstrated by MIBG-SPECT

AU - Druschky, Katrin

AU - Hilz, Max Joseph

AU - Koelsch, Christof

AU - Platsch, Günther

AU - Neundoerfer, Bernhard

PY - 1999/5/28

Y1 - 1999/5/28

N2 - We investigated cardiac sympathetic innervation by metaiodobenzylguanidine (MIBG) imaging in a patient with tonic pupils, loss of tendon reflexes, and segmental anhidrosis (Ross syndrome). Despite normal cardiovascular reflex tests, we observed a reduced global myocardial MIBG uptake as well as a regional uptake defect over the posterolateral cardiac territory indicating left ventricular peripheral sympathetic denervation. MIBG imaging seems to be a useful noninvasive diagnostic method for detection of early - possibly subclinical - cardiac autonomic impairment in Ross syndrome and provides further evidence of injury to postganglionic autonomic neurons as the underlying pathological mechanism of the disease.

AB - We investigated cardiac sympathetic innervation by metaiodobenzylguanidine (MIBG) imaging in a patient with tonic pupils, loss of tendon reflexes, and segmental anhidrosis (Ross syndrome). Despite normal cardiovascular reflex tests, we observed a reduced global myocardial MIBG uptake as well as a regional uptake defect over the posterolateral cardiac territory indicating left ventricular peripheral sympathetic denervation. MIBG imaging seems to be a useful noninvasive diagnostic method for detection of early - possibly subclinical - cardiac autonomic impairment in Ross syndrome and provides further evidence of injury to postganglionic autonomic neurons as the underlying pathological mechanism of the disease.

KW - Cardiac sympathetic denervation

KW - MIBG imaging

KW - Ross syndrome

UR - https://www.scopus.com/pages/publications/0033036504

U2 - 10.1016/S0165-1838(99)00018-1

DO - 10.1016/S0165-1838(99)00018-1

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AN - SCOPUS:0033036504

SN - 0165-1838

VL - 76

SP - 184

EP - 187

JO - Journal of the Autonomic Nervous System

JF - Journal of the Autonomic Nervous System

IS - 2-3

ER -

Cardiac sympathetic denervation in Ross syndrome demonstrated by MIBG-SPECT

Abstract

Keywords

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