Cardiac risk factors and potential treatments in Alzheimer's disease

Christine Bergmann, Mary Sano

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Dementia is one of the commonest neurological disorders in the elderly population. In regards to the increasing longevity of populations worldwide, prevention of dementia has become a major public health challenge. There has been an intense research in the identification of modifiable risk factors for dementia. These risk factors could then be used as targets for intervention, pharmacologic or non-pharmacologic. Numerous reports of the relation between cardiovascular risk factors and cognitive decline and dementia have been published over the past years. This review focuses on the cardiovascular risk factors hypertension, hyperlipidemia and diabetes mellitus as targets for prevention of cognitive decline, overall dementia and Alzheimer's disease. Observational studies and clinical trials regarding the association between antihypertensive, lipid lowering and antidiabetic medications and the risk of impaired cognition, dementia or Alzheimer's disease are reviewed. Based on these data, we propose that early interventions at reducing these cardiovascular risk factors may have an impact on future incidence and prevalence of cognitive deficits of many etiologies including Alzheimer's disease.

Original languageEnglish
Pages (from-to)595-604
Number of pages10
JournalNeurological Research
Volume28
Issue number6
DOIs
StatePublished - Sep 2006

Keywords

  • Alzheimer's disease
  • Cognition
  • Diabetes mellitus
  • Hyperlipidemia
  • Hypertension
  • Risk factor

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