Carcinoma of the anus treated with a combination of radiotherapy and chemotherapy

H. W. Bruckner, M. K. Spigelman, E. Mandel, C. Cohen, G. Deppe, R. Turell, J. Schiavone

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


The treatment of squamous cell tumors of the anus with a combination of chemotherapy and radiotherapy has recently been described for both resectable and unresectable disease. The chemotherapy consisted of 5-fluorouracil (5-FU) given as an iv infusion and mitomycin C. We report here three patients with squamous cell carcinoma of the anus who, after failing attempted curative resection, were treated with modifications of these regimens. These are the first reported cases of patients with regional disease after surgery who have received this treatment and have remained in continuous complete remission for >1 year. The results indicate the ability of these modalities to produce complete remissions in patients failing to respond to surgery, and suggest the potential ability to cure such patients.

Original languageEnglish
Pages (from-to)395-398
Number of pages4
JournalCancer Treatment Reports
Issue number3
StatePublished - 1979


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