TY - JOUR
T1 - Carcinoid Flush
T2 - Role of Gastrin and Somatostatin
AU - Nissenblatt, Michael J.
AU - Thulin, Lars
AU - Samnegård, Hans
AU - Tydén, Gunnar
AU - Long, David H.
AU - Efendić, Suad
AU - Bloomgarden, Zachary T.
AU - Rabinowitz, David
AU - Oates, John A.
PY - 1979/3/15
Y1 - 1979/3/15
N2 - To the Editor: The article on “The Carcinoid Flush” by Frölich et al. in the November 9, 1978, issue of the Journal suggests that the clinical signs may be mediated, either directly or indirectly, by pentagastrin. Case 1 had a foregut carcinoid — of gastric origin. Did hyperhistaminemia change during the infusion of pentagastrin and somatostatin? Were prostaglandins or prostaglandin metabolites measured in any of the patients? Were either of the other two carcinoids of foregut origin? What were the silver staining characteristics? If there is an intermediary between pentagastrin (and gastrin) and the carcinoid flush, one wonders if histamine.
AB - To the Editor: The article on “The Carcinoid Flush” by Frölich et al. in the November 9, 1978, issue of the Journal suggests that the clinical signs may be mediated, either directly or indirectly, by pentagastrin. Case 1 had a foregut carcinoid — of gastric origin. Did hyperhistaminemia change during the infusion of pentagastrin and somatostatin? Were prostaglandins or prostaglandin metabolites measured in any of the patients? Were either of the other two carcinoids of foregut origin? What were the silver staining characteristics? If there is an intermediary between pentagastrin (and gastrin) and the carcinoid flush, one wonders if histamine.
UR - http://www.scopus.com/inward/record.url?scp=0018426142&partnerID=8YFLogxK
U2 - 10.1056/NEJM197903153001113
DO - 10.1056/NEJM197903153001113
M3 - Letter
C2 - 763277
AN - SCOPUS:0018426142
SN - 0028-4793
VL - 300
SP - 624
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 11
ER -