Carbon inhibits vascular endothelial growth factor- and fibroblast growth factor-promoted angiogenesis

Saravanababu Murugesan, Shaker A. Mousa, Laura J. O'Connor, David W. Lincoln, Robert J. Linhardt

Research output: Contribution to journalArticlepeer-review

75 Scopus citations

Abstract

Angiogenesis is important for normal growth and wound healing processes. An imbalance of the growth factors involved in this process, however, causes the acceleration of several diseases including malignant, ocular, and inflammatory diseases. Inhibiting angiogenesis through interfering with its pathway is a promising methodology to hinder the progression of these diseases. Herein, we studied the anti-angiogenic effects of various carbon materials such as graphite, multiwalled carbon nanotubes and fullerenes in vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (FGF2)-induced angiogenesis evaluated in the chick chorioallantoic membrane (CAM) model. All the carbon materials tested showed substantial anti-angiogenic activity against either FGF2- or VEGF-induced angiogenesis in the CAM model. Those carbon materials did not have any significant effects on basal angiogenesis in the absence of the added growth factors.

Original languageEnglish
Pages (from-to)1157-1160
Number of pages4
JournalFEBS Letters
Volume581
Issue number6
DOIs
StatePublished - 20 Mar 2007
Externally publishedYes

Keywords

  • Anti-angiogenic
  • CAM assay
  • Carbon
  • Fullerenes
  • Nanotubes

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