Carbohydrate-protein interactions in vascular biology

Richard M. Nelson, Andre Venot, Michael P. Bevilacqua, Robert J. Linhardt, Ivan Siamenkovic

Research output: Contribution to journalReview articlepeer-review

102 Scopus citations

Abstract

Carbohydrate-protein interactions participate in a wide variety of biological and pathological events. In recent years, particular attention has been paid to the carbohydrate-protein interactions that occur in vascular biology. Sialylated oligosaccharides are ligands of a structurally diverse group of proteins that include the selectins and members of the immunoglobulin superfamily. Various glycosaminoglycans can be recognized by an overlapping set of proteins that include two of the selectins and CD44. Emerging knowledge of carbohydrate-protein interactions in human pathophysiology are discussed.

Original languageEnglish
Pages (from-to)601-631
Number of pages31
JournalAnnual Review of Cell and Developmental Biology
Volume11
DOIs
StatePublished - 1995
Externally publishedYes

Keywords

  • CD22
  • CD44
  • cell adhesion
  • chemokines
  • endothelial cells
  • glycosaminoglycans
  • growth factors
  • selectins

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