CAR T Cell Therapy for Post-Transplant Lymphoproliferative Disorder After Solid Organ Transplantation: A Safe and Feasible Therapy for an Orphan Disease

Uroosa Ibrahim; Claude Bassil; Julio C. Chavez; Farhad Khimani; Michael D. Jain; Frederick L. Locke; Keren Osman; Aleksandr Lazaryan

doi:10.1016/j.clml.2023.05.007

CAR T Cell Therapy for Post-Transplant Lymphoproliferative Disorder After Solid Organ Transplantation: A Safe and Feasible Therapy for an Orphan Disease

Uroosa Ibrahim, Claude Bassil, Julio C. Chavez, Farhad Khimani, Michael D. Jain, Frederick L. Locke, Keren Osman, Aleksandr Lazaryan

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

• CAR T cell therapy can be a safe an effective treatment option for post-transplant lymphoproliferative disorder. • Careful management of immunosuppressive medications before and during the treatment period is required to prevent graft rejection. • Low dose of immunosuppression during CAR T cell therapy can be maintained and may not affect efficacy. • A multidisciplinary team approach throughout the process is essential.

Original language	English
Pages (from-to)	772-778
Number of pages	7
Journal	Clinical Lymphoma, Myeloma and Leukemia
Volume	23
Issue number	10
DOIs	https://doi.org/10.1016/j.clml.2023.05.007
State	Published - Oct 2023

Keywords

Cellular therapy
Diffuse large B cell lymphoma
Liver transplant
Organ rejection
Renal transplant

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title = "CAR T Cell Therapy for Post-Transplant Lymphoproliferative Disorder After Solid Organ Transplantation: A Safe and Feasible Therapy for an Orphan Disease",

abstract = "• CAR T cell therapy can be a safe an effective treatment option for post-transplant lymphoproliferative disorder. • Careful management of immunosuppressive medications before and during the treatment period is required to prevent graft rejection. • Low dose of immunosuppression during CAR T cell therapy can be maintained and may not affect efficacy. • A multidisciplinary team approach throughout the process is essential.",

keywords = "Cellular therapy, Diffuse large B cell lymphoma, Liver transplant, Organ rejection, Renal transplant",

author = "Uroosa Ibrahim and Claude Bassil and Chavez, {Julio C.} and Farhad Khimani and Jain, {Michael D.} and Locke, {Frederick L.} and Keren Osman and Aleksandr Lazaryan",

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doi = "10.1016/j.clml.2023.05.007",

language = "English",

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T1 - CAR T Cell Therapy for Post-Transplant Lymphoproliferative Disorder After Solid Organ Transplantation

T2 - A Safe and Feasible Therapy for an Orphan Disease

AU - Ibrahim, Uroosa

AU - Bassil, Claude

AU - Chavez, Julio C.

AU - Khimani, Farhad

AU - Jain, Michael D.

AU - Locke, Frederick L.

AU - Osman, Keren

AU - Lazaryan, Aleksandr

PY - 2023/10

Y1 - 2023/10

N2 - • CAR T cell therapy can be a safe an effective treatment option for post-transplant lymphoproliferative disorder. • Careful management of immunosuppressive medications before and during the treatment period is required to prevent graft rejection. • Low dose of immunosuppression during CAR T cell therapy can be maintained and may not affect efficacy. • A multidisciplinary team approach throughout the process is essential.

AB - • CAR T cell therapy can be a safe an effective treatment option for post-transplant lymphoproliferative disorder. • Careful management of immunosuppressive medications before and during the treatment period is required to prevent graft rejection. • Low dose of immunosuppression during CAR T cell therapy can be maintained and may not affect efficacy. • A multidisciplinary team approach throughout the process is essential.

KW - Cellular therapy

KW - Diffuse large B cell lymphoma

KW - Liver transplant

KW - Organ rejection

KW - Renal transplant

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U2 - 10.1016/j.clml.2023.05.007

DO - 10.1016/j.clml.2023.05.007

M3 - Article

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JO - Clinical Lymphoma, Myeloma and Leukemia

JF - Clinical Lymphoma, Myeloma and Leukemia

IS - 10

ER -

CAR T Cell Therapy for Post-Transplant Lymphoproliferative Disorder After Solid Organ Transplantation: A Safe and Feasible Therapy for an Orphan Disease

Abstract

Keywords

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