TY - JOUR
T1 - CancerPPD
T2 - A database of anticancer peptides and proteins
AU - Tyagi, Atul
AU - Tuknait, Abhishek
AU - Anand, Priya
AU - Gupta, Sudheer
AU - Sharma, Minakshi
AU - Mathur, Deepika
AU - Joshi, Anshika
AU - Singh, Sandeep
AU - Gautam, Ankur
AU - Raghava, Gajendra P.S.
N1 - Publisher Copyright:
© The Author(s) 2014.
PY - 2015/1/28
Y1 - 2015/1/28
N2 - CancerPPD (http://crdd.osdd.net/raghava/cancerppd/) is a repository of experimentally verified anticancer peptides (ACPs) and anticancer proteins. Data were manually collected from published research articles, patents and from other databases. The current release of CancerPPD consists of 3491 ACP and 121 anticancer protein entries. Each entry provides comprehensive information related to a peptide like its source of origin, nature of the peptide, anticancer activity, N- and C-terminal modifications, conformation, etc. Additionally, CancerPPD provides the information of around 249 types of cancer cell lines and 16 different assays used for testing the ACPs. In addition to natural peptides, CancerPPD contains peptides having non-natural, chemically modified residues and D-amino acids. Besides this primary information, CancerPPD stores predicted tertiary structures as well as peptide sequences in SMILES format. Tertiary structures of peptides were predicted using the state-of-art method, PEPstr and secondary structural states were assigned using DSSP. In order to assist users, a number of web-based tools have been integrated, these include keyword search, data browsing, sequence and structural similarity search. We believe that CancerPPD will be very useful in designing peptide-based anticancer therapeutics.
AB - CancerPPD (http://crdd.osdd.net/raghava/cancerppd/) is a repository of experimentally verified anticancer peptides (ACPs) and anticancer proteins. Data were manually collected from published research articles, patents and from other databases. The current release of CancerPPD consists of 3491 ACP and 121 anticancer protein entries. Each entry provides comprehensive information related to a peptide like its source of origin, nature of the peptide, anticancer activity, N- and C-terminal modifications, conformation, etc. Additionally, CancerPPD provides the information of around 249 types of cancer cell lines and 16 different assays used for testing the ACPs. In addition to natural peptides, CancerPPD contains peptides having non-natural, chemically modified residues and D-amino acids. Besides this primary information, CancerPPD stores predicted tertiary structures as well as peptide sequences in SMILES format. Tertiary structures of peptides were predicted using the state-of-art method, PEPstr and secondary structural states were assigned using DSSP. In order to assist users, a number of web-based tools have been integrated, these include keyword search, data browsing, sequence and structural similarity search. We believe that CancerPPD will be very useful in designing peptide-based anticancer therapeutics.
UR - http://www.scopus.com/inward/record.url?scp=84941040040&partnerID=8YFLogxK
U2 - 10.1093/nar/gku892
DO - 10.1093/nar/gku892
M3 - Article
C2 - 25270878
AN - SCOPUS:84941040040
SN - 0305-1048
VL - 43
SP - D837-D843
JO - Nucleic Acids Research
JF - Nucleic Acids Research
IS - D1
ER -