TY - JOUR
T1 - Cancer incidence and mortality in a cohort of chloroprene workers from Armenia
AU - Bulbulyan, Mariana A.
AU - Margaryan, Anait G.
AU - Ilychova, Svetlana A.
AU - Astashevsky, Sergey V.
AU - Uloyan, Sirush M.
AU - Cogan, Vladimir Y.
AU - Colin, Didier
AU - Boffetta, Paolo
AU - Zaridze, David G.
PY - 1999
Y1 - 1999
N2 - We evaluated the risk of cancer among 1897 men and 417 women exposed to chloroprene (2-chloro-1,3-butadiene, CP) at a production plant in Yerevan, Armenia, between 1940 and 1988. The cohort was followed up for cancer incidence for the years 1979-1990 and for cancer mortality for 1979-1988. In the cohort, incidence and mortality from all cancers were below expectation, but increased incidence (standardized incidence ratio 3.27, 95% confidence interval [CI] 1.47-7.27), and mortality (standardized mortality ratio 3.39, 95% CI 1.09-10.5) from liver cancer were noticed. A dose-response relationship was suggested between liver cancer and indices of CP exposure, such as duration of employment, duration of high CP exposure and cumulative exposure to CP. The risk of other neoplasms was not increased.
AB - We evaluated the risk of cancer among 1897 men and 417 women exposed to chloroprene (2-chloro-1,3-butadiene, CP) at a production plant in Yerevan, Armenia, between 1940 and 1988. The cohort was followed up for cancer incidence for the years 1979-1990 and for cancer mortality for 1979-1988. In the cohort, incidence and mortality from all cancers were below expectation, but increased incidence (standardized incidence ratio 3.27, 95% confidence interval [CI] 1.47-7.27), and mortality (standardized mortality ratio 3.39, 95% CI 1.09-10.5) from liver cancer were noticed. A dose-response relationship was suggested between liver cancer and indices of CP exposure, such as duration of employment, duration of high CP exposure and cumulative exposure to CP. The risk of other neoplasms was not increased.
UR - http://www.scopus.com/inward/record.url?scp=0032977427&partnerID=8YFLogxK
U2 - 10.1002/(sici)1097-0215(19990331)81:1<31::aid-ijc6>3.0.co;2-t
DO - 10.1002/(sici)1097-0215(19990331)81:1<31::aid-ijc6>3.0.co;2-t
M3 - Article
C2 - 10077148
AN - SCOPUS:0032977427
SN - 0020-7136
VL - 81
SP - 31
EP - 33
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 1
ER -