Cancer immunity derailed: PGE2 misconducts cDC1s

Matthew Brown; Michelle A. Tran; Nina Bhardwaj

doi:10.1016/j.immuni.2023.05.015

Cancer immunity derailed: PGE₂ misconducts cDC1s

Matthew Brown
, Michelle A. Tran
, Nina Bhardwaj

Research output: Contribution to journal › Comment/debate

5 Scopus citations

Abstract

Type 1 conventional dendritic cells (cDC1s) are critical for CD8⁺ T cell-mediated tumor control. In this issue of Immunity, Bayerl et al.¹ expose a mechanism leading to cancer progression where prostaglandin E₂ induces dysfunctional cDC1s, which cannot coordinate CD8⁺ T cell migration and expansion.

Original language	English
Pages (from-to)	1165-1167
Number of pages	3
Journal	Immunity
Volume	56
Issue number	6
DOIs	https://doi.org/10.1016/j.immuni.2023.05.015
State	Published - 13 Jun 2023

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10.1016/j.immuni.2023.05.015

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@article{d2dae4e0b76d4a74bd914a085fdd52b3,

title = "Cancer immunity derailed: PGE2 misconducts cDC1s",

abstract = "Type 1 conventional dendritic cells (cDC1s) are critical for CD8+ T cell-mediated tumor control. In this issue of Immunity, Bayerl et al.1 expose a mechanism leading to cancer progression where prostaglandin E2 induces dysfunctional cDC1s, which cannot coordinate CD8+ T cell migration and expansion.",

author = "Matthew Brown and Tran, \{Michelle A.\} and Nina Bhardwaj",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",

year = "2023",

month = jun,

day = "13",

doi = "10.1016/j.immuni.2023.05.015",

language = "English",

volume = "56",

pages = "1165--1167",

journal = "Immunity",

issn = "1074-7613",

publisher = "Cell Press",

number = "6",

}

TY - JOUR

T1 - Cancer immunity derailed

T2 - PGE2 misconducts cDC1s

AU - Brown, Matthew

AU - Tran, Michelle A.

AU - Bhardwaj, Nina

PY - 2023/6/13

Y1 - 2023/6/13

N2 - Type 1 conventional dendritic cells (cDC1s) are critical for CD8+ T cell-mediated tumor control. In this issue of Immunity, Bayerl et al.1 expose a mechanism leading to cancer progression where prostaglandin E2 induces dysfunctional cDC1s, which cannot coordinate CD8+ T cell migration and expansion.

AB - Type 1 conventional dendritic cells (cDC1s) are critical for CD8+ T cell-mediated tumor control. In this issue of Immunity, Bayerl et al.1 expose a mechanism leading to cancer progression where prostaglandin E2 induces dysfunctional cDC1s, which cannot coordinate CD8+ T cell migration and expansion.

UR - https://www.scopus.com/pages/publications/85161085854

U2 - 10.1016/j.immuni.2023.05.015

DO - 10.1016/j.immuni.2023.05.015

M3 - Comment/debate

AN - SCOPUS:85161085854

SN - 1074-7613

VL - 56

SP - 1165

EP - 1167

JO - Immunity

JF - Immunity

IS - 6

ER -

Cancer immunity derailed: PGE2 misconducts cDC1s

Abstract

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Cancer immunity derailed: PGE₂ misconducts cDC1s