Calcospherites in pituitary prolactinomas. A Hypothesis for their formation

S. Lipper, H. D. Isenberg, L. B. Kahn

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Calcospherites are being reported with increasing frequency in pituitary prolactinomas. Ultrastructural study of such a case, along with the recent characterization of the molecular composition of prolactin granules, has led us to hypothesize that a unique intracellular millieu exists in which calcification can be initiated and can proceed to calcospherite formation.

Original languageEnglish
Pages (from-to)31-34
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Issue number1
StatePublished - 1984
Externally publishedYes


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