Abstract
Pluripotent and post-natal, tissue-specific stem cells share functional features such as the capacity to differentiate into multiple lineages and to self-renew, and are endowed with specific cell maintenance mechanism as well as transcriptional and epigenetic signatures that determine stem cell identity and distinguish them from their progeny. Calcium is a highly versatile and ubiquitous second messenger that regulates a wide variety of cellular functions. Specific roles of calcium in stem cell niches and stem cell maintenance mechanisms are only beginning to be explored, however. In this review, I discuss stem cell-specific regulation and roles of calcium, focusing on its potential involvement in the intertwined metabolic and epigenetic regulation of stem cells.
Original language | English |
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Article number | e50028 |
Journal | EMBO Reports |
Volume | 21 |
Issue number | 6 |
DOIs | |
State | Published - 4 Jun 2020 |
Externally published | Yes |
Keywords
- calcium
- epigenetics
- metabolism
- pluripotent stem cells
- post-natal stem cells