Calcium regulation of stem cells

Hans Willem Snoeck

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations

Abstract

Pluripotent and post-natal, tissue-specific stem cells share functional features such as the capacity to differentiate into multiple lineages and to self-renew, and are endowed with specific cell maintenance mechanism as well as transcriptional and epigenetic signatures that determine stem cell identity and distinguish them from their progeny. Calcium is a highly versatile and ubiquitous second messenger that regulates a wide variety of cellular functions. Specific roles of calcium in stem cell niches and stem cell maintenance mechanisms are only beginning to be explored, however. In this review, I discuss stem cell-specific regulation and roles of calcium, focusing on its potential involvement in the intertwined metabolic and epigenetic regulation of stem cells.

Original languageEnglish
Article numbere50028
JournalEMBO Reports
Volume21
Issue number6
DOIs
StatePublished - 4 Jun 2020
Externally publishedYes

Keywords

  • calcium
  • epigenetics
  • metabolism
  • pluripotent stem cells
  • post-natal stem cells

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