Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner

Joseph D. Buxbaum, Astrid A. Ruefli, Carolyn A. Parker, Aaron M. Cypess, Paul Greengard

Research output: Contribution to journalArticlepeer-review

172 Scopus citations

Abstract

Various first messengers linked to phospholipase C, including acetylcholine and interleukin 1, regulate the production both of the secreted form of the amyloid protein precursor (APP) and of amyloid β-protein. We have now identified intracellular signals which are responsible for mediating these effects. We show that activation of phospholipase C may affect APP processing by either of two pathways, one involving an increase in protein kinase C and the other an increase in cytoplasmic calcium levels. The effects of calcium on APP processing appear to be independent of protein kinase C activation. The observed effects of calcium on APP processing may be of therapeutic utility.

Original languageEnglish
Pages (from-to)4489-4493
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume91
Issue number10
DOIs
StatePublished - 10 May 1994
Externally publishedYes

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