Calcitonin gene‐related peptide desensitizes skeletal muscle arterioles to substance P in vivo

Anders Öhlén, N. Peter Wiklund, Magnus G. Persson, Per Hedqvist

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Calcitonin gene‐related peptide (CGRP) was tested for possible interactions with the effects of substance P on rabbit skeletal muscle arterioles in vivo. Both CGRP and substance P dose‐dependently increased arteriolar diameter. However, pretreatment with CGRP made the arterioles insensitive to substance P, and also prevented the formation of aggregates of leukocytes and platelets normally seen after substance P. These results suggest that CGRP, in addition to its direct effects, may act as a modulator of the effects of substance P in neurogenic inflammation. 1988 British Pharmacological Society

Original languageEnglish
Pages (from-to)673-674
Number of pages2
JournalBritish Journal of Pharmacology
Volume95
Issue number3
DOIs
StatePublished - Nov 1988
Externally publishedYes

Fingerprint

Dive into the research topics of 'Calcitonin gene‐related peptide desensitizes skeletal muscle arterioles to substance P in vivo'. Together they form a unique fingerprint.

Cite this