Calcific Aortic Valve Stenosis with Aging and Current Development in its Pathophysiology

Arber Kodra, Michael Kim

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Aortic stenosis is the most common valvular heart disease affecting the elderly. While most patients have a prolonged asymptomatic phase, the development of symptoms ushers in a phase clinical deterioration that often leads to sudden death without an intervention. Treatment of aortic stenosis with valve replacement often relieves the symptoms but still leaves behind a remodeled left ventricle which may not recover. Understanding the pathophysiology of aortic stenosis and realizing that the disease process may be a more active biological entity rather than a passive degenerative process will help us prevent it. This review serves to summarize the latest literature on the pathophysiology of aortic stenosis in the elderly.

Original languageEnglish
Pages (from-to)229-231
Number of pages3
JournalInternational Journal of Angiology
Issue number4
StatePublished - 1 Dec 2022
Externally publishedYes


  • advanced glycosylation end product
  • aortic valve disease
  • atherosclerosis
  • biomarkers
  • cardiovascular risk factors
  • valvular heart disease


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