TY - JOUR
T1 - CADgene
T2 - A comprehensive database for coronary artery disease genes
AU - Liu, Hui
AU - Liu, Wei
AU - Liao, Yifang
AU - Cheng, Long
AU - Liu, Qian
AU - Ren, Xiang
AU - Shi, Lisong
AU - Tu, Xin
AU - Wang, Qing Kenneth
AU - Guo, An Yuan
N1 - Funding Information:
Starting Fund from Huazhong University of Science and Technology (to A.Y.G.); Fundamental Research Funds for the Central Universities (2010MS045 to A.Y.G. and 2010MS015); China National 863 Scientific Program (2006AA02Z476); China National Basic Research Programs (973 Programs 2007CB512000); Key Academic Program Leader Award of Wuhan City (200951830560); Hubei Province Natural Science Key Program (2008CDA047); China National Natural Science Foundation (NSF30670857, 30800457). Funding for open access charge: China National Basic Research Programs (973 Programs 2007CB512000).
PY - 2011/1
Y1 - 2011/1
N2 - Coronary artery disease (CAD) is a complex, multifactorial disease and a leading cause of mortality world wide. Over the past decades, great efforts have been made to elucidate the underlying genetic basis of CAD and massive data have been accumulated. To integrate these data together and to provide a useful resource for researchers, we developed the CADgene, a comprehensive database for CAD genes. We manually extracted CAD-related evidence for more than 300 candidate genes for CAD from over 1300 publications of genetic studies. We classified these candidate genes into 12 functional categories based on their roles in CAD. For each gene, we extracted detailed information from related studies (e.g. the size of case-control, population, SNP, odds ratio, P-value, etc.) and made useful annotations, which include general gene information, Gene Ontology annotations, KEGG pathways, protein-protein interactions and others. Besides the statistical number of studies for each gene, CADgene also provides tools to search and show the most frequently studied candidate genes. In addition, CADgene provides cumulative data from 11 publications of CAD-related genome-wide association studies. CADgene has a user-friendly web interface with multiple browse and search functions. It is freely available at http://www.bioguo.org/CADgene/.
AB - Coronary artery disease (CAD) is a complex, multifactorial disease and a leading cause of mortality world wide. Over the past decades, great efforts have been made to elucidate the underlying genetic basis of CAD and massive data have been accumulated. To integrate these data together and to provide a useful resource for researchers, we developed the CADgene, a comprehensive database for CAD genes. We manually extracted CAD-related evidence for more than 300 candidate genes for CAD from over 1300 publications of genetic studies. We classified these candidate genes into 12 functional categories based on their roles in CAD. For each gene, we extracted detailed information from related studies (e.g. the size of case-control, population, SNP, odds ratio, P-value, etc.) and made useful annotations, which include general gene information, Gene Ontology annotations, KEGG pathways, protein-protein interactions and others. Besides the statistical number of studies for each gene, CADgene also provides tools to search and show the most frequently studied candidate genes. In addition, CADgene provides cumulative data from 11 publications of CAD-related genome-wide association studies. CADgene has a user-friendly web interface with multiple browse and search functions. It is freely available at http://www.bioguo.org/CADgene/.
UR - https://www.scopus.com/pages/publications/78651271677
U2 - 10.1093/nar/gkq1106
DO - 10.1093/nar/gkq1106
M3 - Article
C2 - 21045063
AN - SCOPUS:78651271677
SN - 0305-1048
VL - 39
SP - D991-D996
JO - Nucleic Acids Research
JF - Nucleic Acids Research
IS - SUPPL. 1
ER -