CA 125 levels in the preoperative assessment of advanced-stage uterine cancer

Helen Jhang, Linus Chuang, Paul Visintainer, Gita Ramaswamy

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

OBJECTIVE: The purpose of this study was too evaluate preoperative levels of CA 125 in for the prediction of advanced uterine cancer. STUDY DESIGN: We conducted a retrospective analysis of the correlation of preoperative CA 125 with grade, depth of invasion, lymph vascular space involvement, lymph node status, and stage. RESULTS: High CA 125 levels correlated with advanced-stage (P < .0001) and positive (P < .0001) lymph node status. High levels of CA 125 also correlated with the deepest myometrial invasion, the presence of lymph vascular space involvement, and the highest grade. Receiver-operator characteristic curves demonstrated that depth of invasion, lymph vascular space involvement, and grade accurately predicted advanced-stage disease 73%, 77% and 80% of the time, respectively. CA 125 levels, however, correctly predicted advanced stage 94% of the time. The sensitivity and specificity of a CA 125 cutoff level of 37 IU/mL were 95% and 90%, respectively, with a positive predictive value of 78% and a negative predictive value of 97%. CONCLUSION: CA 125 appears to be a significant independent predictor of positive lymph node status and the extrauterine spread of disease.

Original languageEnglish
Pages (from-to)1195-1197
Number of pages3
JournalAmerican Journal of Obstetrics and Gynecology
Volume188
Issue number5
DOIs
StatePublished - 1 May 2003
Externally publishedYes

Keywords

  • Advanced stage
  • CA 125
  • Preoperative assessment
  • Uterine cancer

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