TY - JOUR
T1 - C957T DRD2 polymorphism is associated with schizophrenia in Spanish patients
AU - Hoenicka, J.
AU - Aragüés, M.
AU - Rodríguez-Jiménez, R.
AU - Ponce, G.
AU - Martínez, I.
AU - Rubio, G.
AU - Jiménez-Arriero, M. A.
AU - Palomo, T.
AU - Cano, P.
AU - Díez, J.
AU - Holgado, P.
AU - Muñiz, M. J.
AU - Rodríguez-Torresano, J.
AU - Sánchez, R.
AU - Sanz, J.
AU - Vega, S.
AU - Gimeno, D.
AU - Alfonso, S.
PY - 2006/12
Y1 - 2006/12
N2 - Objective: The objective was to confirm whether a homozygous genotype for the C957 allele of the C957T DRD2 gene single nucleotide polymorphism (SNP) is associated with schizophrenia in an independent study population. Method: We examined the genotypic distribution of this SNP in a set of clinically ascertained schizophrenic patients (n = 131) and age-matched control subjects (n = 364). Individuals were genotyped using automated analysis of fluorescently labeled PCR products. Results: The distribution of grouped genotypes for the C957T DRD2 SNP (CC vs. CT, TT) showed that C homozygote genotype was over-represented in our patient sample when compared with control subjects. This difference reaches the statistical significance (χ2 = 7.0; df = 1; P = 0.008; OR = 2.05; % CI 1.2-3.4). Conclusion: The findings of this study provide additional evidence that genetic variation at the DRD2 gene plays an important role in the vulnerability to schizophrenia.
AB - Objective: The objective was to confirm whether a homozygous genotype for the C957 allele of the C957T DRD2 gene single nucleotide polymorphism (SNP) is associated with schizophrenia in an independent study population. Method: We examined the genotypic distribution of this SNP in a set of clinically ascertained schizophrenic patients (n = 131) and age-matched control subjects (n = 364). Individuals were genotyped using automated analysis of fluorescently labeled PCR products. Results: The distribution of grouped genotypes for the C957T DRD2 SNP (CC vs. CT, TT) showed that C homozygote genotype was over-represented in our patient sample when compared with control subjects. This difference reaches the statistical significance (χ2 = 7.0; df = 1; P = 0.008; OR = 2.05; % CI 1.2-3.4). Conclusion: The findings of this study provide additional evidence that genetic variation at the DRD2 gene plays an important role in the vulnerability to schizophrenia.
KW - Dopamine
KW - Dopamine-D2 receptor
KW - Genetic polymorphism
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=33750732291&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0447.2006.00874.x
DO - 10.1111/j.1600-0447.2006.00874.x
M3 - Article
C2 - 17087792
AN - SCOPUS:33750732291
SN - 0001-690X
VL - 114
SP - 435
EP - 438
JO - Acta Psychiatrica Scandinavica
JF - Acta Psychiatrica Scandinavica
IS - 6
ER -