TY - JOUR
T1 - C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages
AU - Hoeffel, Guillaume
AU - Chen, Jinmiao
AU - Lavin, Yonit
AU - Low, Donovan
AU - Almeida, Francisca F.
AU - See, Peter
AU - Beaudin, Anna E.
AU - Lum, Josephine
AU - Low, Ivy
AU - Forsberg, E. Camilla
AU - Poidinger, Michael
AU - Zolezzi, Francesca
AU - Larbi, Anis
AU - Ng, Lai Guan
AU - Chan, Jerry K.Y.
AU - Greter, Melanie
AU - Becher, Burkhard
AU - Samokhvalov, Igor M.
AU - Merad, Miriam
AU - Ginhoux, Florent
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/4/21
Y1 - 2015/4/21
N2 - Although classified as hematopoietic cells, tissue-resident macrophages (MFs) arise from embryonic precursors that seed the tissues prior to birth togenerate a self-renewing population, which is maintained independently of adult hematopoiesis. Here we reveal the identity of these embryonic precursors using an in utero MF-depletion strategy and fate-mapping of yolk sac (YS) and fetal liver (FL) hematopoiesis. We show that YS MFs are the main precursors of microglia, while most other MFs derive from fetal monocytes (MOs). Both YS MFs and fetal MOs arise from erythro-myeloid progenitors (EMPs) generated in the YS. In the YS, EMPs gave rise to MFs without monocytic intermediates, while EMP seeding the FL upon the establishment of blood circulation acquired c-Myb expression and gave rise to fetal MOs that then seeded embryonic tissues and differentiated into MFs. Thus, adult tissue-resident MFs established from hematopoietic stem cell-independent embryonic precursors arise from two distinct developmental programs.
AB - Although classified as hematopoietic cells, tissue-resident macrophages (MFs) arise from embryonic precursors that seed the tissues prior to birth togenerate a self-renewing population, which is maintained independently of adult hematopoiesis. Here we reveal the identity of these embryonic precursors using an in utero MF-depletion strategy and fate-mapping of yolk sac (YS) and fetal liver (FL) hematopoiesis. We show that YS MFs are the main precursors of microglia, while most other MFs derive from fetal monocytes (MOs). Both YS MFs and fetal MOs arise from erythro-myeloid progenitors (EMPs) generated in the YS. In the YS, EMPs gave rise to MFs without monocytic intermediates, while EMP seeding the FL upon the establishment of blood circulation acquired c-Myb expression and gave rise to fetal MOs that then seeded embryonic tissues and differentiated into MFs. Thus, adult tissue-resident MFs established from hematopoietic stem cell-independent embryonic precursors arise from two distinct developmental programs.
UR - https://www.scopus.com/pages/publications/84928189502
U2 - 10.1016/j.immuni.2015.03.011
DO - 10.1016/j.immuni.2015.03.011
M3 - Article
C2 - 25902481
AN - SCOPUS:84928189502
SN - 1074-7613
VL - 42
SP - 665
EP - 678
JO - Immunity
JF - Immunity
IS - 4
ER -