Abstract
The specifics: A synthesis of the sesquiterpenoid antibiotic (+)-hongoquercin A using sequential site-specific C-H methylation and oxidation reactions is described. A key advancement toward this goal was the development of a ligand-accelerated C-H methylation reaction, and enabled the generation of a library of eight structurally diverse analogues.
Original language | English |
---|---|
Pages (from-to) | 7317-7320 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 52 |
Issue number | 28 |
DOIs | |
State | Published - 8 Jul 2013 |
Externally published | Yes |
Keywords
- C-H functionalization
- natural products
- oxidation
- synthesis design
- synthetic methods