C-H functionalization logic enables synthesis of (+)-hongoquercin A and related compounds

Brandon R. Rosen, Leah R. Simke, Peter S. Thuy-Boun, Darryl D. Dixon, Jin Quan Yu, Phil S. Baran

Research output: Contribution to journalArticlepeer-review

134 Scopus citations


The specifics: A synthesis of the sesquiterpenoid antibiotic (+)-hongoquercin A using sequential site-specific C-H methylation and oxidation reactions is described. A key advancement toward this goal was the development of a ligand-accelerated C-H methylation reaction, and enabled the generation of a library of eight structurally diverse analogues.

Original languageEnglish
Pages (from-to)7317-7320
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number28
StatePublished - 8 Jul 2013
Externally publishedYes


  • C-H functionalization
  • natural products
  • oxidation
  • synthesis design
  • synthetic methods


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