C-fos protein expression in Spitz nevi, common melanocytic nevi, and malignant melanomas

Reuven Bergman, Hedviga Kerner, Lena Manov, Rachel Friedman-Birnbaum

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13 Scopus citations


The expression of c-fos protein was studied in formalin-fixed, paraffin- embedded sections of 11 compound Spitz nevi (SNs), 16 ordinary compound melanocytic nevi (MNs), and 17 malignant melanomas (MMs) using monoclonal antibody MAB 1283 and an immunoperoxidase technique. Eleven (100%) SNs, 15 (94%) MNs, and 16 (94%) MMs showed positive reactions in some of the tumor cells (p = nonsignificant). In the majority of the tumors the staining was located in nuclei and graded as moderate to strong in intensity. The percentages of positively stained cells did not differentiate the three types of tumor, although they were higher in the melanocytic nevi. Most of the lesions with a significant dermal component did not show stratification of staining with progressive descent into the dermis. Positive staining for c- fos was also frequently found in the normal skin constituents within and adjacent to the melanocytic tumors. In conclusion, the pattern of expression of c-los in routinely processed specimens does not differentiate between SNs, MNs, and MMs.

Original languageEnglish
Pages (from-to)262-265
Number of pages4
JournalAmerican Journal of Dermatopathology
Issue number3
StatePublished - 1998
Externally publishedYes


  • C-fos
  • Melanoma
  • Spitz nevus


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