Buspirone decreases the activity of 5‐hydroxytryptamine‐containing dorsal raphe neurons in‐vitro

Michael E. Trulson, Kamyar Arasteh

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Buspirone, a non‐benzodiazepine anxiolytic agent, produced a dose‐dependent decrease in the activity of 5‐HT‐containing dorsal raphe neurons recorded from mouse brain slices. The response was not changed in a low calcium/high magnesium incubation medium, indicating that the observed effects were the result of a direct action of buspirone on raphe neurons. These data are discussed within the context of the anxiolytic effects of buspirone.

Original languageEnglish
Pages (from-to)380-382
Number of pages3
JournalJournal of Pharmacy and Pharmacology
Volume38
Issue number5
DOIs
StatePublished - May 1986
Externally publishedYes

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