@article{b54d282c21be447a8b7d34f9ffa53b87,
title = "Bulimia nervosa and evidence for striatal dopamine dysregulation: A conceptual review",
abstract = "Objective: This article reviews concepts and evidence, based in particular on the work of Bartley G. Hoebel and colleagues, which suggest that a better understanding of the role of striatal dopamine (DA) in the initiation and/or maintenance of bulimia nervosa (BN) may result in a clearer characterization of mechanisms underlying BN. Methods: Literature review, using PubMed search. Results: Several lines of evidence, including the work of Bartley G. Hoebel, implicate the importance of striatal DA in feeding behavior, as well as in the disordered eating behaviors relevant to BN. Preclinical models of 'BN-like' eating behaviors have been associated with changes in striatal DA and DA receptor measures. Emerging clinical research also suggests that striatal DA abnormalities exist in individuals with BN. Conclusion: Alterations in striatal DA may exist in patients with BN. While the precise relationship between these findings and the etiology and maintenance of bulimic symptomatology remains unclear, further investigation of brain DA systems is a fruitful avenue of future research in BN.",
keywords = "Bulimia nervosa, Dopamine, Eating disorders, PET imaging, Reward, Substance abuse",
author = "Broft, {Allegra I.} and Berner, {Laura A.} and Diana Martinez and Walsh, {B. Timothy}",
note = "Funding Information: The authors respectfully acknowledge Bartley G. Hoebel, Ph.D., for his longstanding commitment to the science of eating, and for preclinical research that lays groundwork for reward-related translational research approaches in eating disorders. The authors would also like to thank Evelyn Attia, MD, Nicole Barbarich-Marsteller, PhD, Michael Devlin, MD, Diane Klein, MD, Laurel Mayer, MD, and Joanna Steinglass, MD for their contributions to this manuscript. This publication was made possible by NIMH grants T32MH15144 , R21MH65024 , and K23MH082097 , a 2006 NARSAD Junior Investigator Award, and grant number KL2 RR024157 from the National Center for Research Resources (NCRR) , a component of the National Institutes of Health (NIH), and NIH Roadmap for Medical Research . Its contents are solely the responsibility of the authors and do not necessarily represent the official view of NCRR or NIH. Information on NCRR is available at http://www.ncrr.nih.gov/ . Information on Re-engineering the Clinical Research Enterprise can be obtained from http://nihroadmap.nih.gov/clinicalresearch/overview-translational.asp .",
year = "2011",
month = jul,
day = "25",
doi = "10.1016/j.physbeh.2011.04.028",
language = "English",
volume = "104",
pages = "122--127",
journal = "Physiology and Behavior",
issn = "0031-9384",
publisher = "Elsevier Inc.",
number = "1",
}