Building Programs to Eradicate Toxoplasmosis Part IV: Understanding and Development of Public Health Strategies and Advances “Take a Village”

Mariangela Soberón Felín; Kanix Wang; Aliya Moreira; Andrew Grose; Karen Leahy; Ying Zhou; Fatima Alibana Clouser; Maryam Siddiqui; Nicole Leong; Perpetua Goodall; Morgan Michalowski; Mahmoud Ismail; Monica Christmas; Stephen Schrantz; Zuleima Caballero; Ximena Norero; Dora Estripeaut; David Ellis; Catalina Raggi; Catherine Castro; Davina Moossazadeh; Margarita Ramirez; Abhinav Pandey; Kevin Ashi; Samantha Dovgin; Ashtyn Dixon; Xuan Li; Ian Begeman; Sharon Heichman; Joseph Lykins; Delba Villalobos-Cerrud; Lorena Fabrega; José Luis Sanchez Montalvo; Connie Mendivil; Mario R. Quijada; Silvia Fernández-Pirla; Valli de La Guardia; Digna Wong; Mayrene Ladrón de Guevara; Carlos Flores; Jovanna Borace; Anabel García; Natividad Caballero; Claudia Rengifo-Herrera; Maria Theresa Moreno de Saez; Michael Politis; Stephanie Ross; Mimansa Dogra; Vishan Dhamsania; Nicholas Graves; Marci Kirchberg; Kopal Mathur; Ashley Aue; Carlos M. Restrepo; Alejandro Llanes; German Guzman; Arturo Rebellon; Kenneth Boyer; Peter Heydemann; A. Gwendolyn Noble; Charles Swisher; Peter Rabiah; Shawn Withers; Teri Hull; David Frim; David McLone; Chunlei Su; Michael Blair; Paul Latkany; Ernest Mui; Daniel Vitor Vasconcelos-Santos; Alcibiades Villareal; Ambar Perez; Carlos Andrés Naranjo Galvis; Mónica Vargas Montes; Nestor Ivan Cardona Perez; Morgan Ramirez; Cy Chittenden; Edward Wang; Laura Lorena Garcia-López; Guillermo Padrieu; Juliana Muñoz-Ortiz; Nicolás Rivera-Valdivia; María Cristina Bohorquez-Granados; Gabriela Castaño de-la-Torre; Juan David Valencia Hernandez; Daniel Celis-Giraldo; Juan Alejandro Acosta Dávila; Elizabeth Torres; Manuela Mejia Oquendo; José Y. Arteaga-Rivera; Dan L. Nicolae; Andrey Rzhetsky; Nancy Roizen; Eileen Stillwaggon; Larry Sawers; Francois Peyron; Martine Wallon; Emanuelle Chapey; Pauline Levigne; Carmen Charter; Migdalia De Frias; Jose Montoya; Cindy Press; Raymund Ramirez; Despina Contopoulos-Ioannidis; Yvonne Maldonado; Oliver Liesenfeld; Carlos Gomez; Kelsey Wheeler; Samantha Zehar; James McAuley; Denis Limonne; Sandrine Houze; Sylvie Abraham; Raphael Piarroux; Vera Tesic; Kathleen Beavis; Ana Abeleda; Mari Sautter; Bouchra El Mansouri; Adlaoui El Bachir; Fatima Amarir; Kamal El Bissati; Ellen Holfels; David Frim; David McLone; Richard Penn; William Cohen; Alejandra de-la-Torre; Gabrielle Britton; Jorge Motta; Eduardo Ortega-Barria; Isabel Luz Romero; Paul Meier; Michael Grigg; Jorge Gómez-Marín; Jagannatha Rao Kosagisharaf; Xavier Sáez Llorens; Osvaldo Reyes; Rima McLeod

doi:10.1007/s40124-022-00268-x

Building Programs to Eradicate Toxoplasmosis Part IV: Understanding and Development of Public Health Strategies and Advances “Take a Village”

Mariangela Soberón Felín, Kanix Wang, Aliya Moreira, Andrew Grose, Karen Leahy, Ying Zhou, Fatima Alibana Clouser, Maryam Siddiqui, Nicole Leong, Perpetua Goodall, Morgan Michalowski, Mahmoud Ismail, Monica Christmas, Stephen Schrantz, Zuleima Caballero, Ximena Norero, Dora Estripeaut, David Ellis, Catalina Raggi, Catherine CastroDavina Moossazadeh, Margarita Ramirez, Abhinav Pandey, Kevin Ashi, Samantha Dovgin, Ashtyn Dixon, Xuan Li, Ian Begeman, Sharon Heichman, Joseph Lykins, Delba Villalobos-Cerrud, Lorena Fabrega, José Luis Sanchez Montalvo, Connie Mendivil, Mario R. Quijada, Silvia Fernández-Pirla, Valli de La Guardia, Digna Wong, Mayrene Ladrón de Guevara, Carlos Flores, Jovanna Borace, Anabel García, Natividad Caballero, Claudia Rengifo-Herrera, Maria Theresa Moreno de Saez, Michael Politis, Stephanie Ross, Mimansa Dogra, Vishan Dhamsania, Nicholas Graves, Marci Kirchberg, Kopal Mathur, Ashley Aue, Carlos M. Restrepo, Alejandro Llanes, German Guzman, Arturo Rebellon, Kenneth Boyer, Peter Heydemann, A. Gwendolyn Noble, Charles Swisher, Peter Rabiah, Shawn Withers, Teri Hull, David Frim, David McLone, Chunlei Su, Michael Blair, Paul Latkany, Ernest Mui, Daniel Vitor Vasconcelos-Santos, Alcibiades Villareal, Ambar Perez, Carlos Andrés Naranjo Galvis, Mónica Vargas Montes, Nestor Ivan Cardona Perez, Morgan Ramirez, Cy Chittenden, Edward Wang, Laura Lorena Garcia-López, Guillermo Padrieu, Juliana Muñoz-Ortiz, Nicolás Rivera-Valdivia, María Cristina Bohorquez-Granados, Gabriela Castaño de-la-Torre, Juan David Valencia Hernandez, Daniel Celis-Giraldo, Juan Alejandro Acosta Dávila, Elizabeth Torres, Manuela Mejia Oquendo, José Y. Arteaga-Rivera, Dan L. Nicolae, Andrey Rzhetsky, Nancy Roizen, Eileen Stillwaggon, Larry Sawers, Francois Peyron, Martine Wallon, Emanuelle Chapey, Pauline Levigne, Carmen Charter, Migdalia De Frias, Jose Montoya, Cindy Press, Raymund Ramirez, Despina Contopoulos-Ioannidis, Yvonne Maldonado, Oliver Liesenfeld, Carlos Gomez, Kelsey Wheeler, Samantha Zehar, James McAuley, Denis Limonne, Sandrine Houze, Sylvie Abraham, Raphael Piarroux, Vera Tesic, Kathleen Beavis, Ana Abeleda, Mari Sautter, Bouchra El Mansouri, Adlaoui El Bachir, Fatima Amarir, Kamal El Bissati, Ellen Holfels, David Frim, David McLone, Richard Penn, William Cohen, Alejandra de-la-Torre, Gabrielle Britton, Jorge Motta, Eduardo Ortega-Barria, Isabel Luz Romero, Paul Meier, Michael Grigg, Jorge Gómez-Marín, Jagannatha Rao Kosagisharaf, Xavier Sáez Llorens, Osvaldo Reyes, Rima McLeod

Research output: Contribution to journal › Review article › peer-review

Abstract

Purpose of Review: Review international efforts to build a global public health initiative focused on toxoplasmosis with spillover benefits to save lives, sight, cognition and motor function benefiting maternal and child health. Recent Findings: Multiple countries’ efforts to eliminate toxoplasmosis demonstrate progress and context for this review and new work. Summary: Problems with potential solutions proposed include accessibility of accurate, inexpensive diagnostic testing, pre-natal screening and facilitating tools, missed and delayed neonatal diagnosis, restricted access, high costs, delays in obtaining medicines emergently, delayed insurance pre-approvals and high medicare copays taking considerable physician time and effort, harmful shortcuts being taken in methods to prepare medicines in settings where access is restricted, reluctance to perform ventriculoperitoneal shunts promptly when needed without recognition of potential benefit, access to resources for care, especially for marginalized populations, and limited use of recent advances in management of neurologic and retinal disease which can lead to good outcomes.

Original language	English
Pages (from-to)	125-154
Number of pages	30
Journal	Current Pediatrics Reports
Volume	10
Issue number	3
DOIs	https://doi.org/10.1007/s40124-022-00268-x
State	Published - Sep 2022
Externally published	Yes

Keywords

antiparasitic treatment
congenital toxoplasmosis
diagnostic testing
marginalized populations
point-of-care testing
prenatal screening

Access to Document

10.1007/s40124-022-00268-x

Cite this

Felín, M. S., Wang, K., Moreira, A., Grose, A., Leahy, K., Zhou, Y., Clouser, F. A., Siddiqui, M., Leong, N., Goodall, P., Michalowski, M., Ismail, M., Christmas, M., Schrantz, S., Caballero, Z., Norero, X., Estripeaut, D., Ellis, D., Raggi, C., ... McLeod, R. (2022). Building Programs to Eradicate Toxoplasmosis Part IV: Understanding and Development of Public Health Strategies and Advances “Take a Village”. Current Pediatrics Reports, 10(3), 125-154. https://doi.org/10.1007/s40124-022-00268-x

@article{d6cf1562adb94142a141b83c1caaa9c0,

title = "Building Programs to Eradicate Toxoplasmosis Part IV: Understanding and Development of Public Health Strategies and Advances “Take a Village”",

abstract = "Purpose of Review: Review international efforts to build a global public health initiative focused on toxoplasmosis with spillover benefits to save lives, sight, cognition and motor function benefiting maternal and child health. Recent Findings: Multiple countries{\textquoteright} efforts to eliminate toxoplasmosis demonstrate progress and context for this review and new work. Summary: Problems with potential solutions proposed include accessibility of accurate, inexpensive diagnostic testing, pre-natal screening and facilitating tools, missed and delayed neonatal diagnosis, restricted access, high costs, delays in obtaining medicines emergently, delayed insurance pre-approvals and high medicare copays taking considerable physician time and effort, harmful shortcuts being taken in methods to prepare medicines in settings where access is restricted, reluctance to perform ventriculoperitoneal shunts promptly when needed without recognition of potential benefit, access to resources for care, especially for marginalized populations, and limited use of recent advances in management of neurologic and retinal disease which can lead to good outcomes.",

keywords = "antiparasitic treatment, congenital toxoplasmosis, diagnostic testing, marginalized populations, point-of-care testing, prenatal screening",

author = "Fel{\'i}n, {Mariangela Sober{\'o}n} and Kanix Wang and Aliya Moreira and Andrew Grose and Karen Leahy and Ying Zhou and Clouser, {Fatima Alibana} and Maryam Siddiqui and Nicole Leong and Perpetua Goodall and Morgan Michalowski and Mahmoud Ismail and Monica Christmas and Stephen Schrantz and Zuleima Caballero and Ximena Norero and Dora Estripeaut and David Ellis and Catalina Raggi and Catherine Castro and Davina Moossazadeh and Margarita Ramirez and Abhinav Pandey and Kevin Ashi and Samantha Dovgin and Ashtyn Dixon and Xuan Li and Ian Begeman and Sharon Heichman and Joseph Lykins and Delba Villalobos-Cerrud and Lorena Fabrega and Montalvo, {Jos{\'e} Luis Sanchez} and Connie Mendivil and Quijada, {Mario R.} and Silvia Fern{\'a}ndez-Pirla and {de La Guardia}, Valli and Digna Wong and {de Guevara}, {Mayrene Ladr{\'o}n} and Carlos Flores and Jovanna Borace and Anabel Garc{\'i}a and Natividad Caballero and Claudia Rengifo-Herrera and {de Saez}, {Maria Theresa Moreno} and Michael Politis and Stephanie Ross and Mimansa Dogra and Vishan Dhamsania and Nicholas Graves and Marci Kirchberg and Kopal Mathur and Ashley Aue and Restrepo, {Carlos M.} and Alejandro Llanes and German Guzman and Arturo Rebellon and Kenneth Boyer and Peter Heydemann and Noble, {A. Gwendolyn} and Charles Swisher and Peter Rabiah and Shawn Withers and Teri Hull and David Frim and David McLone and Chunlei Su and Michael Blair and Paul Latkany and Ernest Mui and Vasconcelos-Santos, {Daniel Vitor} and Alcibiades Villareal and Ambar Perez and Galvis, {Carlos Andr{\'e}s Naranjo} and Montes, {M{\'o}nica Vargas} and Perez, {Nestor Ivan Cardona} and Morgan Ramirez and Cy Chittenden and Edward Wang and Garcia-L{\'o}pez, {Laura Lorena} and Guillermo Padrieu and Juliana Mu{\~n}oz-Ortiz and Nicol{\'a}s Rivera-Valdivia and Bohorquez-Granados, {Mar{\'i}a Cristina} and de-la-Torre, {Gabriela Casta{\~n}o} and Hernandez, {Juan David Valencia} and Daniel Celis-Giraldo and D{\'a}vila, {Juan Alejandro Acosta} and Elizabeth Torres and Oquendo, {Manuela Mejia} and Arteaga-Rivera, {Jos{\'e} Y.} and Nicolae, {Dan L.} and Andrey Rzhetsky and Nancy Roizen and Eileen Stillwaggon and Larry Sawers and Francois Peyron and Martine Wallon and Emanuelle Chapey and Pauline Levigne and Carmen Charter and {De Frias}, Migdalia and Jose Montoya and Cindy Press and Raymund Ramirez and Despina Contopoulos-Ioannidis and Yvonne Maldonado and Oliver Liesenfeld and Carlos Gomez and Kelsey Wheeler and Samantha Zehar and James McAuley and Denis Limonne and Sandrine Houze and Sylvie Abraham and Raphael Piarroux and Vera Tesic and Kathleen Beavis and Ana Abeleda and Mari Sautter and {El Mansouri}, Bouchra and {El Bachir}, Adlaoui and Fatima Amarir and {El Bissati}, Kamal and Ellen Holfels and David Frim and David McLone and Richard Penn and William Cohen and Alejandra de-la-Torre and Gabrielle Britton and Jorge Motta and Eduardo Ortega-Barria and Romero, {Isabel Luz} and Paul Meier and Michael Grigg and Jorge G{\'o}mez-Mar{\'i}n and Kosagisharaf, {Jagannatha Rao} and Llorens, {Xavier S{\'a}ez} and Osvaldo Reyes and Rima McLeod",

note = "Funding Information: Additional thanks for funding from the Jeff Metcalf Internship Program, the Margaret P Thorp Scholarship Fund, the American College of Obstetricians and Gynecologists for their Medical Student Award, the National Institute of Diabetes and Digestive and Kidney Diseases for their Grant #T35DK062719-30, the American Society of Tropical Medicine and Hygiene for their Benjamin H. Kean Fellowship, the National Institutes of Health for their Division of Microbiology and Infectious Diseases Grants to RMc #R01 AI2753,RO1 16945, AI08749-01A1 BIOL-3 , U01 AI77887, U01 AI082180, TMP R01-AI071319, the Thrasher Research Fund for their E.W. “Al” Thrasher Award, the Kiphardt Global-Local Health Seed Fund Award, University of Chicago. SENACYT. Research to Prevent Blindness Foundation, and March of Dimes (6-528), FDA , MRI, Pillsbury Foundation. Michael Reese Physicians Research and Education Foundation, Fullbright Scholar Awards (Craig Roberts, Kamal ElBissati; Dorota Nowakowska), Pathological Society of Great Britain and Northern Ireland Travel Award, WHO DIF, Stanley Foundation, This work was supported in part by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases, NIH (Michael Grigg).. Funding Information: We gratefully acknowledge the following organizations and people for their financial, logistical and/or technical support during our work on this project. Panam{\'a}: Thanks to the Secretar{\'i}a Nacional de Ciencia, Tecnolog{\'i}a e Innovaci{\'o}n (SENACYT), the Sistema Nacional de Investigaci{\'o}n (SNI), the Institute for Scientific Research and High Technology Services of Panama (INDICASAT), Hospital del Ni{\~n}o, Hospital Santo Tom{\'a}s, and Roche Diagnostics International Ltd. Special thanks to the medical staff of the high-risk pregnancy and infectious disease wings of Hospital Santo Tom{\'a}s, especially Aris Caballero de Mendieta, Susana Fr{\'i}as, Dario Beneditto, Edwin Ortiz, Carlos Moreno, Ana Belen Arauz, Monica Pachar, Eyra Garcia, as well as to the nurses for all their logistical support. We thank little Henry Arosemena, who was the impetus for starting the program in Panama and the Arosemena family for their support of educational initiatives in Panam{\'a}. Colombia: Thanks to the Grupo de Investigaci{\'o}n en Parasitolog{\'i}a Molecular (GEPAMOL) at the University of Quind{\'i}o, to Richard James Orozco Gonz{\'a}lez and to Hospital del Sur and Hospital San Juan de Dios in Armenia, Colombia. United States: Thanks to Dr. Brian Callender, Dr. Jeanne Farnan, Dr. Olofunmilayo Olopade, Absera Melaku, MPH, Kristyna Hulland, MS, Dr. Susan Duncan and Dr. John Schneider for facilitating summer research through the Summer Research Program at the Pritzker School of Medicine at Chicago. We appreciate Aaron Ponsler{\textquoteright}s suggestion at a Thrasher Foundation site visit at Stanford University that the LDBio could do the most good if it were cleared by the FDA and waived by CLIA. We thank all those in the National Collaborative Chicago Based Congenital Toxoplasmosis Study (NCCCTS) who helped build and sustain programs in the United States. We especially thank the many families who participated in and/or encouraged these initiatives and their primary care physicians. We give special thanks to these participant families and their physicians without whom this NCCCTS could not have been performed. We thank all those who traveled to Springfield to begin these in the United States, recognizing the importance this would have for their families, and who, in addition, participated in testing of the Point of Care test allowing the work that validated its use in the United States with genetically divergent Toxoplasma. We thank those who worked with the NCCCTS in the earlier years including Marilyn Mets, William Mieler, Michael Grassi, Michael Kip, Hassan Shah, Diane Patton, Vicky Aithchison, Holly McGinnis, Randee Estes, Douglas Mack, Michael Kirisits, Adrian Esquivel, Toria Trendler, Simone Cezar, Jessica Coyne, Daniel Lee, Jane Babiarz, Veena Arun, Annie Kuo, Laura Phan, as well as Daniel Johnson, Adil Javed and others as reflected in the author lists in references 3 –50. Their contributions to the initial phases of this work were substantial and valuable. We thank additional authors and members of the NCCCTS group Barbara Danis, Mark Stein, Linda Pfiffner, Jeanne Perkins, Sanford Meyers, Balaji Gupta, Ahmed Abdelsalam, Huiyuan Zhang, John Marcinak, Saeid Mojatahedi, Dianna Bardo, Carina Yang, Delilah Burrowes, John Collins Marisha Humphries, Douglas Mack, Michael J. Kirisits, Diana Chamot, Ronald Thisted and (University of Chicago, Chicago, IL); Lazlo Stein (Northwestern University, Chicago; deceased); Andrew Suth (Argosy University, Chicago); Audrey Cameron (Mount Sinai Hospital, Chicago); Marie Weissbourd (Northwestern University Hospital, Chicago); Joyce Hopkins (Illinois Institute of Technology, Chicago); Dushyant Patel (Michael Reese Medical Center, Chicago); and others. We gratefully acknowledge Kristen Wroblewski MS and Theodore Karrison PhD{\textquoteright}s assistance with many aspects of this work with the NCCCTS and assisting with analyses. We thank Jack Remington and those in the Remington serology laboratory who performed the serologic testing for participants in the NCCCTS establishing the diagnosis for each participant as part of their clinical care, allowing the NCCCTS study to be based on rigorous, meticulous diagnostic criteria. We thank the Data Safety Monitoring Board members, John Flagherty, MD, Rchard Chappell PhD, David Mittelman MD, Dana Bradzunias MD. We thank those working with us to establish gestational screening for perinatal infections and to develop and test WHO-compatible POC tests in the United States, France and Morocco, Mohamed Rhajaoui, Amina Barkat, Hua Cong and Bo Shiun Lai. Additionally, we thank Shaun Carey, James Lynch, Millie Malekar, others in the IRB office, Jim Rago and Sam Campbell for photography, David G Goodman, Colin Shephard, Ribhi M.Shawar, Matthew Macgilvray and Steven Gitterman for their guidance with FDA processes, NIH DMID Program, Michael Gottlieb, F. Lee Hall, Stephanie James and John Rogers for many suggestions, Additional Morocco Group colleagues working alongside and with us, help and support in implementing prenatal screening for toxoplasmosis in Morocco. We thank Iris Ramirez for her contribution to screening. We thank Tom Lint for assistance with many aspects of the study. France/Austria: Many thanks to our French and Austrian colleagues, who paved the way to and worked with us in understanding the importance of prompt gestational screening, treatment and prevention of congenital toxoplasmosis. We thank and greatfully acknowledge our scientific colleagues working with us in our basic science, immunology, molecular biology, medicinal chemistry,systems biology, formulation, vaccine and medicine development programs as shown in Fig. 5 and also throughout the work as referenced. We thank Dr. Lago, Dr. Gupta and Dr. Goldstein for their helpful suggestions. Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = sep,

doi = "10.1007/s40124-022-00268-x",

language = "English",

volume = "10",

pages = "125--154",

journal = "Current Pediatrics Reports",

issn = "2167-4841",

publisher = "Springer Science and Business Media B.V.",

number = "3",

}

Felín, MS, Wang, K, Moreira, A, Grose, A, Leahy, K, Zhou, Y, Clouser, FA, Siddiqui, M, Leong, N, Goodall, P, Michalowski, M, Ismail, M, Christmas, M, Schrantz, S, Caballero, Z, Norero, X, Estripeaut, D, Ellis, D, Raggi, C, Castro, C, Moossazadeh, D, Ramirez, M, Pandey, A, Ashi, K, Dovgin, S, Dixon, A, Li, X, Begeman, I, Heichman, S, Lykins, J, Villalobos-Cerrud, D, Fabrega, L, Montalvo, JLS, Mendivil, C, Quijada, MR, Fernández-Pirla, S, de La Guardia, V, Wong, D, de Guevara, ML, Flores, C, Borace, J, García, A, Caballero, N, Rengifo-Herrera, C, de Saez, MTM, Politis, M, Ross, S, Dogra, M, Dhamsania, V, Graves, N, Kirchberg, M, Mathur, K, Aue, A, Restrepo, CM, Llanes, A, Guzman, G, Rebellon, A, Boyer, K, Heydemann, P, Noble, AG, Swisher, C, Rabiah, P, Withers, S, Hull, T, Frim, D, McLone, D, Su, C, Blair, M, Latkany, P, Mui, E, Vasconcelos-Santos, DV, Villareal, A, Perez, A, Galvis, CAN, Montes, MV, Perez, NIC, Ramirez, M, Chittenden, C, Wang, E, Garcia-López, LL, Padrieu, G, Muñoz-Ortiz, J, Rivera-Valdivia, N, Bohorquez-Granados, MC, de-la-Torre, GC, Hernandez, JDV, Celis-Giraldo, D, Dávila, JAA, Torres, E, Oquendo, MM, Arteaga-Rivera, JY, Nicolae, DL, Rzhetsky, A, Roizen, N, Stillwaggon, E, Sawers, L, Peyron, F, Wallon, M, Chapey, E, Levigne, P, Charter, C, De Frias, M, Montoya, J, Press, C, Ramirez, R, Contopoulos-Ioannidis, D, Maldonado, Y, Liesenfeld, O, Gomez, C, Wheeler, K, Zehar, S, McAuley, J, Limonne, D, Houze, S, Abraham, S, Piarroux, R, Tesic, V, Beavis, K, Abeleda, A, Sautter, M, El Mansouri, B, El Bachir, A, Amarir, F, El Bissati, K, Holfels, E, Frim, D, McLone, D, Penn, R, Cohen, W, de-la-Torre, A, Britton, G, Motta, J, Ortega-Barria, E, Romero, IL, Meier, P, Grigg, M, Gómez-Marín, J, Kosagisharaf, JR, Llorens, XS, Reyes, O & McLeod, R 2022, 'Building Programs to Eradicate Toxoplasmosis Part IV: Understanding and Development of Public Health Strategies and Advances “Take a Village”', Current Pediatrics Reports, vol. 10, no. 3, pp. 125-154. https://doi.org/10.1007/s40124-022-00268-x

TY - JOUR

T1 - Building Programs to Eradicate Toxoplasmosis Part IV

T2 - Understanding and Development of Public Health Strategies and Advances “Take a Village”

AU - Felín, Mariangela Soberón

AU - Wang, Kanix

AU - Moreira, Aliya

AU - Grose, Andrew

AU - Leahy, Karen

AU - Zhou, Ying

AU - Clouser, Fatima Alibana

AU - Siddiqui, Maryam

AU - Leong, Nicole

AU - Goodall, Perpetua

AU - Michalowski, Morgan

AU - Ismail, Mahmoud

AU - Christmas, Monica

AU - Schrantz, Stephen

AU - Caballero, Zuleima

AU - Norero, Ximena

AU - Estripeaut, Dora

AU - Ellis, David

AU - Raggi, Catalina

AU - Castro, Catherine

AU - Moossazadeh, Davina

AU - Ramirez, Margarita

AU - Pandey, Abhinav

AU - Ashi, Kevin

AU - Dovgin, Samantha

AU - Dixon, Ashtyn

AU - Li, Xuan

AU - Begeman, Ian

AU - Heichman, Sharon

AU - Lykins, Joseph

AU - Villalobos-Cerrud, Delba

AU - Fabrega, Lorena

AU - Montalvo, José Luis Sanchez

AU - Mendivil, Connie

AU - Quijada, Mario R.

AU - Fernández-Pirla, Silvia

AU - de La Guardia, Valli

AU - Wong, Digna

AU - de Guevara, Mayrene Ladrón

AU - Flores, Carlos

AU - Borace, Jovanna

AU - García, Anabel

AU - Caballero, Natividad

AU - Rengifo-Herrera, Claudia

AU - de Saez, Maria Theresa Moreno

AU - Politis, Michael

AU - Ross, Stephanie

AU - Dogra, Mimansa

AU - Dhamsania, Vishan

AU - Graves, Nicholas

AU - Kirchberg, Marci

AU - Mathur, Kopal

AU - Aue, Ashley

AU - Restrepo, Carlos M.

AU - Llanes, Alejandro

AU - Guzman, German

AU - Rebellon, Arturo

AU - Boyer, Kenneth

AU - Heydemann, Peter

AU - Noble, A. Gwendolyn

AU - Swisher, Charles

AU - Rabiah, Peter

AU - Withers, Shawn

AU - Hull, Teri

AU - Frim, David

AU - McLone, David

AU - Su, Chunlei

AU - Blair, Michael

AU - Latkany, Paul

AU - Mui, Ernest

AU - Vasconcelos-Santos, Daniel Vitor

AU - Villareal, Alcibiades

AU - Perez, Ambar

AU - Galvis, Carlos Andrés Naranjo

AU - Montes, Mónica Vargas

AU - Perez, Nestor Ivan Cardona

AU - Ramirez, Morgan

AU - Chittenden, Cy

AU - Wang, Edward

AU - Garcia-López, Laura Lorena

AU - Padrieu, Guillermo

AU - Muñoz-Ortiz, Juliana

AU - Rivera-Valdivia, Nicolás

AU - Bohorquez-Granados, María Cristina

AU - de-la-Torre, Gabriela Castaño

AU - Hernandez, Juan David Valencia

AU - Celis-Giraldo, Daniel

AU - Dávila, Juan Alejandro Acosta

AU - Torres, Elizabeth

AU - Oquendo, Manuela Mejia

AU - Arteaga-Rivera, José Y.

AU - Nicolae, Dan L.

AU - Rzhetsky, Andrey

AU - Roizen, Nancy

AU - Stillwaggon, Eileen

AU - Sawers, Larry

AU - Peyron, Francois

AU - Wallon, Martine

AU - Chapey, Emanuelle

AU - Levigne, Pauline

AU - Charter, Carmen

AU - De Frias, Migdalia

AU - Montoya, Jose

AU - Press, Cindy

AU - Ramirez, Raymund

AU - Contopoulos-Ioannidis, Despina

AU - Maldonado, Yvonne

AU - Liesenfeld, Oliver

AU - Gomez, Carlos

AU - Wheeler, Kelsey

AU - Zehar, Samantha

AU - McAuley, James

AU - Limonne, Denis

AU - Houze, Sandrine

AU - Abraham, Sylvie

AU - Piarroux, Raphael

AU - Tesic, Vera

AU - Beavis, Kathleen

AU - Abeleda, Ana

AU - Sautter, Mari

AU - El Mansouri, Bouchra

AU - El Bachir, Adlaoui

AU - Amarir, Fatima

AU - El Bissati, Kamal

AU - Holfels, Ellen

AU - Frim, David

AU - McLone, David

AU - Penn, Richard

AU - Cohen, William

AU - de-la-Torre, Alejandra

AU - Britton, Gabrielle

AU - Motta, Jorge

AU - Ortega-Barria, Eduardo

AU - Romero, Isabel Luz

AU - Meier, Paul

AU - Grigg, Michael

AU - Gómez-Marín, Jorge

AU - Kosagisharaf, Jagannatha Rao

AU - Llorens, Xavier Sáez

AU - Reyes, Osvaldo

AU - McLeod, Rima

N1 - Funding Information: Additional thanks for funding from the Jeff Metcalf Internship Program, the Margaret P Thorp Scholarship Fund, the American College of Obstetricians and Gynecologists for their Medical Student Award, the National Institute of Diabetes and Digestive and Kidney Diseases for their Grant #T35DK062719-30, the American Society of Tropical Medicine and Hygiene for their Benjamin H. Kean Fellowship, the National Institutes of Health for their Division of Microbiology and Infectious Diseases Grants to RMc #R01 AI2753,RO1 16945, AI08749-01A1 BIOL-3 , U01 AI77887, U01 AI082180, TMP R01-AI071319, the Thrasher Research Fund for their E.W. “Al” Thrasher Award, the Kiphardt Global-Local Health Seed Fund Award, University of Chicago. SENACYT. Research to Prevent Blindness Foundation, and March of Dimes (6-528), FDA , MRI, Pillsbury Foundation. Michael Reese Physicians Research and Education Foundation, Fullbright Scholar Awards (Craig Roberts, Kamal ElBissati; Dorota Nowakowska), Pathological Society of Great Britain and Northern Ireland Travel Award, WHO DIF, Stanley Foundation, This work was supported in part by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases, NIH (Michael Grigg).. Funding Information: We gratefully acknowledge the following organizations and people for their financial, logistical and/or technical support during our work on this project. Panamá: Thanks to the Secretaría Nacional de Ciencia, Tecnología e Innovación (SENACYT), the Sistema Nacional de Investigación (SNI), the Institute for Scientific Research and High Technology Services of Panama (INDICASAT), Hospital del Niño, Hospital Santo Tomás, and Roche Diagnostics International Ltd. Special thanks to the medical staff of the high-risk pregnancy and infectious disease wings of Hospital Santo Tomás, especially Aris Caballero de Mendieta, Susana Frías, Dario Beneditto, Edwin Ortiz, Carlos Moreno, Ana Belen Arauz, Monica Pachar, Eyra Garcia, as well as to the nurses for all their logistical support. We thank little Henry Arosemena, who was the impetus for starting the program in Panama and the Arosemena family for their support of educational initiatives in Panamá. Colombia: Thanks to the Grupo de Investigación en Parasitología Molecular (GEPAMOL) at the University of Quindío, to Richard James Orozco González and to Hospital del Sur and Hospital San Juan de Dios in Armenia, Colombia. United States: Thanks to Dr. Brian Callender, Dr. Jeanne Farnan, Dr. Olofunmilayo Olopade, Absera Melaku, MPH, Kristyna Hulland, MS, Dr. Susan Duncan and Dr. John Schneider for facilitating summer research through the Summer Research Program at the Pritzker School of Medicine at Chicago. We appreciate Aaron Ponsler’s suggestion at a Thrasher Foundation site visit at Stanford University that the LDBio could do the most good if it were cleared by the FDA and waived by CLIA. We thank all those in the National Collaborative Chicago Based Congenital Toxoplasmosis Study (NCCCTS) who helped build and sustain programs in the United States. We especially thank the many families who participated in and/or encouraged these initiatives and their primary care physicians. We give special thanks to these participant families and their physicians without whom this NCCCTS could not have been performed. We thank all those who traveled to Springfield to begin these in the United States, recognizing the importance this would have for their families, and who, in addition, participated in testing of the Point of Care test allowing the work that validated its use in the United States with genetically divergent Toxoplasma. We thank those who worked with the NCCCTS in the earlier years including Marilyn Mets, William Mieler, Michael Grassi, Michael Kip, Hassan Shah, Diane Patton, Vicky Aithchison, Holly McGinnis, Randee Estes, Douglas Mack, Michael Kirisits, Adrian Esquivel, Toria Trendler, Simone Cezar, Jessica Coyne, Daniel Lee, Jane Babiarz, Veena Arun, Annie Kuo, Laura Phan, as well as Daniel Johnson, Adil Javed and others as reflected in the author lists in references 3 –50. Their contributions to the initial phases of this work were substantial and valuable. We thank additional authors and members of the NCCCTS group Barbara Danis, Mark Stein, Linda Pfiffner, Jeanne Perkins, Sanford Meyers, Balaji Gupta, Ahmed Abdelsalam, Huiyuan Zhang, John Marcinak, Saeid Mojatahedi, Dianna Bardo, Carina Yang, Delilah Burrowes, John Collins Marisha Humphries, Douglas Mack, Michael J. Kirisits, Diana Chamot, Ronald Thisted and (University of Chicago, Chicago, IL); Lazlo Stein (Northwestern University, Chicago; deceased); Andrew Suth (Argosy University, Chicago); Audrey Cameron (Mount Sinai Hospital, Chicago); Marie Weissbourd (Northwestern University Hospital, Chicago); Joyce Hopkins (Illinois Institute of Technology, Chicago); Dushyant Patel (Michael Reese Medical Center, Chicago); and others. We gratefully acknowledge Kristen Wroblewski MS and Theodore Karrison PhD’s assistance with many aspects of this work with the NCCCTS and assisting with analyses. We thank Jack Remington and those in the Remington serology laboratory who performed the serologic testing for participants in the NCCCTS establishing the diagnosis for each participant as part of their clinical care, allowing the NCCCTS study to be based on rigorous, meticulous diagnostic criteria. We thank the Data Safety Monitoring Board members, John Flagherty, MD, Rchard Chappell PhD, David Mittelman MD, Dana Bradzunias MD. We thank those working with us to establish gestational screening for perinatal infections and to develop and test WHO-compatible POC tests in the United States, France and Morocco, Mohamed Rhajaoui, Amina Barkat, Hua Cong and Bo Shiun Lai. Additionally, we thank Shaun Carey, James Lynch, Millie Malekar, others in the IRB office, Jim Rago and Sam Campbell for photography, David G Goodman, Colin Shephard, Ribhi M.Shawar, Matthew Macgilvray and Steven Gitterman for their guidance with FDA processes, NIH DMID Program, Michael Gottlieb, F. Lee Hall, Stephanie James and John Rogers for many suggestions, Additional Morocco Group colleagues working alongside and with us, help and support in implementing prenatal screening for toxoplasmosis in Morocco. We thank Iris Ramirez for her contribution to screening. We thank Tom Lint for assistance with many aspects of the study. France/Austria: Many thanks to our French and Austrian colleagues, who paved the way to and worked with us in understanding the importance of prompt gestational screening, treatment and prevention of congenital toxoplasmosis. We thank and greatfully acknowledge our scientific colleagues working with us in our basic science, immunology, molecular biology, medicinal chemistry,systems biology, formulation, vaccine and medicine development programs as shown in Fig. 5 and also throughout the work as referenced. We thank Dr. Lago, Dr. Gupta and Dr. Goldstein for their helpful suggestions. Publisher Copyright: © 2022, The Author(s).

PY - 2022/9

Y1 - 2022/9

N2 - Purpose of Review: Review international efforts to build a global public health initiative focused on toxoplasmosis with spillover benefits to save lives, sight, cognition and motor function benefiting maternal and child health. Recent Findings: Multiple countries’ efforts to eliminate toxoplasmosis demonstrate progress and context for this review and new work. Summary: Problems with potential solutions proposed include accessibility of accurate, inexpensive diagnostic testing, pre-natal screening and facilitating tools, missed and delayed neonatal diagnosis, restricted access, high costs, delays in obtaining medicines emergently, delayed insurance pre-approvals and high medicare copays taking considerable physician time and effort, harmful shortcuts being taken in methods to prepare medicines in settings where access is restricted, reluctance to perform ventriculoperitoneal shunts promptly when needed without recognition of potential benefit, access to resources for care, especially for marginalized populations, and limited use of recent advances in management of neurologic and retinal disease which can lead to good outcomes.

AB - Purpose of Review: Review international efforts to build a global public health initiative focused on toxoplasmosis with spillover benefits to save lives, sight, cognition and motor function benefiting maternal and child health. Recent Findings: Multiple countries’ efforts to eliminate toxoplasmosis demonstrate progress and context for this review and new work. Summary: Problems with potential solutions proposed include accessibility of accurate, inexpensive diagnostic testing, pre-natal screening and facilitating tools, missed and delayed neonatal diagnosis, restricted access, high costs, delays in obtaining medicines emergently, delayed insurance pre-approvals and high medicare copays taking considerable physician time and effort, harmful shortcuts being taken in methods to prepare medicines in settings where access is restricted, reluctance to perform ventriculoperitoneal shunts promptly when needed without recognition of potential benefit, access to resources for care, especially for marginalized populations, and limited use of recent advances in management of neurologic and retinal disease which can lead to good outcomes.

KW - antiparasitic treatment

KW - congenital toxoplasmosis

KW - diagnostic testing

KW - marginalized populations

KW - point-of-care testing

KW - prenatal screening

UR - http://www.scopus.com/inward/record.url?scp=85136785556&partnerID=8YFLogxK

U2 - 10.1007/s40124-022-00268-x

DO - 10.1007/s40124-022-00268-x

M3 - Review article

AN - SCOPUS:85136785556

VL - 10

SP - 125

EP - 154

JO - Current Pediatrics Reports

JF - Current Pediatrics Reports

SN - 2167-4841

IS - 3

ER -

Building Programs to Eradicate Toxoplasmosis Part IV: Understanding and Development of Public Health Strategies and Advances “Take a Village”

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