Building a new conceptual framework for receptor heteromers

Sergi Ferré, Ruben Baler, Michel Bouvier, Marc G. Caron, Lakshmi A. Devi, Thierry Durroux, Kjell Fuxe, Susan R. George, Jonathan A. Javitch, Martin J. Lohse, Ken Mackie, Graeme Milligan, Kevin D.G. Pfleger, Jean Philippe Pin, Nora D. Volkow, Maria Waldhoer, Amina S. Woods, Rafael Franco

Research output: Contribution to journalComment/debate

317 Scopus citations

Abstract

Receptor heteromers constitute a new area of research that is reshaping our thinking about biochemistry, cell biology, pharmacology and drug discovery. In this commentary, we recommend clear definitions that should facilitate both information exchange and research on this growing class of transmembrane signal transduction units and their complex properties. We also consider research questions underlying the proposed nomenclature, with recommendations for receptor heteromer identification in native tissues and their use as targets for drug development.

Original languageEnglish
Pages (from-to)131-134
Number of pages4
JournalNature Chemical Biology
Volume5
Issue number3
DOIs
StatePublished - Mar 2009

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