Broad-spectrum antivirals against viral fusion

Frederic Vigant, Nuno C. Santos, Benhur Lee

Research output: Contribution to journalReview articlepeer-review

158 Scopus citations

Abstract

Effective antivirals have been developed against specific viruses, such as HIV, Hepatitis C virus and influenza virus. This 'one bug-one drug' approach to antiviral drug development can be successful, but it may be inadequate for responding to an increasing diversity of viruses that cause significant diseases in humans. The majority of viral pathogens that cause emerging and re-emerging infectious diseases are membrane-enveloped viruses, which require the fusion of viral and cell membranes for virus entry. Therefore, antivirals that target the membrane fusion process represent new paradigms for broad-spectrum antiviral discovery. In this Review, we discuss the mechanisms responsible for the fusion between virus and cell membranes and explore how broad-spectrum antivirals target this process to prevent virus entry.

Original languageEnglish
Pages (from-to)426-437
Number of pages12
JournalNature Reviews Microbiology
Volume13
Issue number7
DOIs
StatePublished - 18 Jul 2015

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