TY - JOUR
T1 - Brief research communication
T2 - Association study of two polymorphisms of the serotonin-2A receptor gene and suicide attempts
AU - Vaquero-Lorenzo, Concepcion
AU - Baca-Garcia, Enrique
AU - Diaz-Hernandez, Montserrat
AU - Perez-Rodriguez, M. Mercedes
AU - Fernandez-Navarro, Pablo
AU - Giner, Lucas
AU - Carballo, Juan J.
AU - Saiz-Ruiz, Jeronimo
AU - Fernandez-Piqueras, Jose
AU - Baldomero, Enrique Baca
AU - De Leon, Jose
AU - Oquendo, Maria A.
PY - 2008/7/5
Y1 - 2008/7/5
N2 - Serotonin (5-HT) receptors may have a role in suicidal behavior. Previous studies have shown an association between the T102C polymorphism of the 5-HT2a receptor gene and suicidal behavior. However, negative findings have also been reported. We examined the association between the T102C and C1354T (His452Tyr) polymorphisms of the 5-HT2a receptor gene and suicide attempts. Four hundred forty-one suicide attempters, 339 psychiatric patients, and 410 healthy controls were compared for genotypes of the T102C and C1354T (His452Tyr) polymorphisms. There were significant differences in the distribution of the three genotypes (TT, TC, and CC) of the T102C polymorphism in the three groups (controls, psychiatric patients, and suicide attempters). There was an excess of C/C genotypes in the suicide attempter group compared with the control group, but there were no significant differences between suicide attempters and psychiatric controls. We found no association between the C1354T polymorphism and suicide attempts. The C allele of the T102C polymorphism of the 5-HT2A receptor gene may be associated with biological susceptibility for suicidal behavior or psychiatric conditions.
AB - Serotonin (5-HT) receptors may have a role in suicidal behavior. Previous studies have shown an association between the T102C polymorphism of the 5-HT2a receptor gene and suicidal behavior. However, negative findings have also been reported. We examined the association between the T102C and C1354T (His452Tyr) polymorphisms of the 5-HT2a receptor gene and suicide attempts. Four hundred forty-one suicide attempters, 339 psychiatric patients, and 410 healthy controls were compared for genotypes of the T102C and C1354T (His452Tyr) polymorphisms. There were significant differences in the distribution of the three genotypes (TT, TC, and CC) of the T102C polymorphism in the three groups (controls, psychiatric patients, and suicide attempters). There was an excess of C/C genotypes in the suicide attempter group compared with the control group, but there were no significant differences between suicide attempters and psychiatric controls. We found no association between the C1354T polymorphism and suicide attempts. The C allele of the T102C polymorphism of the 5-HT2A receptor gene may be associated with biological susceptibility for suicidal behavior or psychiatric conditions.
KW - A-1438G
KW - C1354T
KW - T102C
UR - http://www.scopus.com/inward/record.url?scp=46949090909&partnerID=8YFLogxK
U2 - 10.1002/ajmg.b.30642
DO - 10.1002/ajmg.b.30642
M3 - Article
C2 - 18163387
AN - SCOPUS:46949090909
SN - 1552-4841
VL - 147
SP - 645
EP - 649
JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
IS - 5
ER -