Brief communication: Rosette-forming human lymphoid cell lines. i. establishment and evidence for origin of thymus-derived lymphocytes12

J. Minowada; T. Ohnuma; G. E. Moore

doi:10.1093/jnci/49.3.891

Brief communication: Rosette-forming human lymphoid cell lines. i. establishment and evidence for origin of thymus-derived lymphocytes¹²

J. Minowada, T. Ohnuma, G. E. Moore

Research output: Contribution to journal › Article › peer-review

1026 Scopus citations

Abstract

Four permanent lymphoid cell lines designated as MOLT #1, 2, 3, and 4 were established from the peripheral blood of a patient with acute lymphoblastic leukemia. The cells resembled relatively mature lymphocytes. Neither immunoglobulins nor Epstein-Barr virus was detectable. No receptors for immunoglobulin or complement were present, but the cells bound with red blood cells of sheep, pig, goat, and horse to form rosettes. These cell lines probably represent a subpopulation of human lymphocytes related to thymus-derived lymphocytes.J Natl Cancer Inst.

Original language	English
Pages (from-to)	891-895
Number of pages	5
Journal	Journal of the National Cancer Institute
Volume	49
Issue number	3
DOIs	https://doi.org/10.1093/jnci/49.3.891
State	Published - Sep 1972
Externally published	Yes

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title = "Brief communication: Rosette-forming human lymphoid cell lines. i. establishment and evidence for origin of thymus-derived lymphocytes12",

abstract = "Four permanent lymphoid cell lines designated as MOLT \#1, 2, 3, and 4 were established from the peripheral blood of a patient with acute lymphoblastic leukemia. The cells resembled relatively mature lymphocytes. Neither immunoglobulins nor Epstein-Barr virus was detectable. No receptors for immunoglobulin or complement were present, but the cells bound with red blood cells of sheep, pig, goat, and horse to form rosettes. These cell lines probably represent a subpopulation of human lymphocytes related to thymus-derived lymphocytes.J Natl Cancer Inst.",

author = "J. Minowada and T. Ohnuma and Moore, \{G. E.\}",

note = "Funding Information: 1 Received June 5,1972; accepted June 16, 1972. 2 Supported by Public Health Service research grants CA10465 and CA05834 from the National Cancer Institute, AI08899 from the National Institute of Allergy and Infectious Diseases, and RR05648 from the Division of Research Resources; NIH General Research Support funds; and a grant from The John A. Hartford Foundation, Inc. a We thank Drs. S. WatanabeandJ. F. Holland for helpful discussion, Drs. Y. Yagi andJ. N. Woody for immune sera, Dr. J.R. Mitchen for electron microscopy, Dr. K. Sako for thoracic duct lymphocytes, and Mrs. J. S. Matheisz and Mrs. A. Simm for their able technical assistance.",

year = "1972",

month = sep,

doi = "10.1093/jnci/49.3.891",

language = "English",

volume = "49",

pages = "891--895",

journal = "Journal of the National Cancer Institute",

issn = "0027-8874",

publisher = "Oxford University Press",

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TY - JOUR

T1 - Brief communication

T2 - Rosette-forming human lymphoid cell lines. i. establishment and evidence for origin of thymus-derived lymphocytes12

AU - Minowada, J.

AU - Ohnuma, T.

AU - Moore, G. E.

N1 - Funding Information: 1 Received June 5,1972; accepted June 16, 1972. 2 Supported by Public Health Service research grants CA10465 and CA05834 from the National Cancer Institute, AI08899 from the National Institute of Allergy and Infectious Diseases, and RR05648 from the Division of Research Resources; NIH General Research Support funds; and a grant from The John A. Hartford Foundation, Inc. a We thank Drs. S. WatanabeandJ. F. Holland for helpful discussion, Drs. Y. Yagi andJ. N. Woody for immune sera, Dr. J.R. Mitchen for electron microscopy, Dr. K. Sako for thoracic duct lymphocytes, and Mrs. J. S. Matheisz and Mrs. A. Simm for their able technical assistance.

PY - 1972/9

Y1 - 1972/9

N2 - Four permanent lymphoid cell lines designated as MOLT #1, 2, 3, and 4 were established from the peripheral blood of a patient with acute lymphoblastic leukemia. The cells resembled relatively mature lymphocytes. Neither immunoglobulins nor Epstein-Barr virus was detectable. No receptors for immunoglobulin or complement were present, but the cells bound with red blood cells of sheep, pig, goat, and horse to form rosettes. These cell lines probably represent a subpopulation of human lymphocytes related to thymus-derived lymphocytes.J Natl Cancer Inst.

AB - Four permanent lymphoid cell lines designated as MOLT #1, 2, 3, and 4 were established from the peripheral blood of a patient with acute lymphoblastic leukemia. The cells resembled relatively mature lymphocytes. Neither immunoglobulins nor Epstein-Barr virus was detectable. No receptors for immunoglobulin or complement were present, but the cells bound with red blood cells of sheep, pig, goat, and horse to form rosettes. These cell lines probably represent a subpopulation of human lymphocytes related to thymus-derived lymphocytes.J Natl Cancer Inst.

UR - https://www.scopus.com/pages/publications/0015394127

U2 - 10.1093/jnci/49.3.891

DO - 10.1093/jnci/49.3.891

M3 - Article

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AN - SCOPUS:0015394127

SN - 0027-8874

VL - 49

SP - 891

EP - 895

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

IS - 3

ER -

Brief communication: Rosette-forming human lymphoid cell lines. i. establishment and evidence for origin of thymus-derived lymphocytes12

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Brief communication: Rosette-forming human lymphoid cell lines. i. establishment and evidence for origin of thymus-derived lymphocytes¹²