Breast leiomyosarcoma: A systematic review and recommendations for management

Mohammed Iyoob Mohammed Ilyas, Sharique Nazir, Philip Q. Xiao

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Background: Leiomyosarcomas of breast are very rare tumors, with only 54 cases reported in the literature to date. Methods: We report a case of leiomyosarcoma in a 52-year-old woman who presented with a painless left breast mass in the upper outer quadrant of her left breast. It measured about 6 cm in diameter and was located within the breast parenchyma with no skin involvement. Mammogram was suggestive of BI-RADS IV lesion, and core biopsy of the lesion was inconclusive. Results: Histopathology and immunohistochemistry of the excision biopsy of the mass confirmed the diagnosis of leiomyosarcoma approaching the specimen margins. The patient underwent simple mastectomy, which did not reveal any residual tumor or additional lesions. Follow-up for a year after her mastectomy did not show any local or systemic recurrence. Conclusions: We reviewed the literature and summarize our findings as recommendations for management of leiomyosarcoma of breast.

Original languageEnglish
Pages (from-to)196-202
Number of pages7
JournalInternational Surgery
Issue number5
StatePublished - May 2019
Externally publishedYes


  • Breast cancer
  • Immunohistochemistry
  • Leiomyosarcoma
  • Mammogram
  • Radiation therapy
  • Sarcoma breast


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