TY - JOUR
T1 - Breast-feeding and serum p,p′DDT levels among Mexican women of childbearing age
T2 - A pilot study
AU - López-Carrillo, Lizbeth
AU - Torres-Sánchez, Luisa
AU - Moline, Jacqueline
AU - Ireland, Karen
AU - Wolff, Mary S.
N1 - Funding Information:
The authors are grateful for the support provided by Ms. Reina Collado for typing the paper and Ms. Esther Freeman for editing. Dr. Luisa Torres is a Selikoff Fellow and Drs. LoH pez-Carrillo, Wolff, and Moline are faculty associated with the Mount Sinai/Queens College International Training Program in Environmental and Occupational Health supported by the Fogarty International Center of the National Institutes of Health (Grant D43 TW00640).
PY - 2001
Y1 - 2001
N2 - For almost 50 years, millions of Mexicans have been directly and/or indirectly exposed to (1,1,1-trichloro-2,2-bis [p-chlorophenyl] ethane) (p,p′DDT). The potential related health outcomes of this exposure are of international concern. The objective of the study was to determine the effect of breast-feeding on serum levels of 1,1-dichloro-2; 2′-bis (p-chlorophenyl)ethylene (p,p′DDE) and p,p′DDT in women of childbearing age who were residents of the state of Morelos, Mexico. In March 1999, we examined a sample of 24 women, ages 21 to 36 years, who came with their children to the outpatient facility of a county Health Center in the state of Morelos. The geometric mean for p,p′DDE was 21.8 ng/ml ± 2.58 (GSD) and 2.9 ng/ml ± 2.84 for p,p′DDT. For each month of breast-feeding we observed similar significant decreases for both p,p′DDE (β = -0.0403 per log concentration unit, P = 0.001) and p,p′DDT (β = -0.0309, P = 0.03) serum levels, adjusted by mothers' age and number of children. The adjusted half-life estimate for p,p′DDE serum levels was 17 months. It was concluded that breast-feeding leads to rapid removal of p,p′DDT from the body (< 2 year half-life) compared to nonlactational elimination rates (<5 year half-life). In this population, serum p,p′DDE levels were similar to those found 20 years ago in the United States.
AB - For almost 50 years, millions of Mexicans have been directly and/or indirectly exposed to (1,1,1-trichloro-2,2-bis [p-chlorophenyl] ethane) (p,p′DDT). The potential related health outcomes of this exposure are of international concern. The objective of the study was to determine the effect of breast-feeding on serum levels of 1,1-dichloro-2; 2′-bis (p-chlorophenyl)ethylene (p,p′DDE) and p,p′DDT in women of childbearing age who were residents of the state of Morelos, Mexico. In March 1999, we examined a sample of 24 women, ages 21 to 36 years, who came with their children to the outpatient facility of a county Health Center in the state of Morelos. The geometric mean for p,p′DDE was 21.8 ng/ml ± 2.58 (GSD) and 2.9 ng/ml ± 2.84 for p,p′DDT. For each month of breast-feeding we observed similar significant decreases for both p,p′DDE (β = -0.0403 per log concentration unit, P = 0.001) and p,p′DDT (β = -0.0309, P = 0.03) serum levels, adjusted by mothers' age and number of children. The adjusted half-life estimate for p,p′DDE serum levels was 17 months. It was concluded that breast-feeding leads to rapid removal of p,p′DDT from the body (< 2 year half-life) compared to nonlactational elimination rates (<5 year half-life). In this population, serum p,p′DDE levels were similar to those found 20 years ago in the United States.
KW - Blood serum
KW - Breast-feeding
KW - Childbearing age
KW - Mexico
KW - Women
KW - p,p′DDE
KW - p,p′DDT
UR - http://www.scopus.com/inward/record.url?scp=0035672868&partnerID=8YFLogxK
U2 - 10.1006/enrs.2001.4296
DO - 10.1006/enrs.2001.4296
M3 - Article
AN - SCOPUS:0035672868
SN - 0013-9351
VL - 87
SP - 131
EP - 135
JO - Environmental Research
JF - Environmental Research
IS - 3
ER -