Brain ventricles as windows into brain development and disease

Phan Q. Duy; Pasko Rakic; Seth L. Alper; William E. Butler; Christopher A. Walsh; Nenad Sestan; Daniel H. Geschwind; Sheng Chih Jin; Kristopher T. Kahle

doi:10.1016/j.neuron.2021.12.009

Brain ventricles as windows into brain development and disease

Phan Q. Duy, Pasko Rakic, Seth L. Alper, William E. Butler, Christopher A. Walsh, Nenad Sestan, Daniel H. Geschwind, Sheng Chih Jin, Kristopher T. Kahle

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Dilation of the fluid-filled cerebral ventricles (ventriculomegaly) characterizes hydrocephalus and is frequently seen in autism and schizophrenia. Recent work suggests that the genomic study of congenital hydrocephalus may be unexpectedly fertile ground for revealing insights into neural stem cell regulation, human cerebrocortical development, and pathogenesis of neuropsychiatric disease.

Original language	English
Pages (from-to)	12-15
Number of pages	4
Journal	Neuron
Volume	110
Issue number	1
DOIs	https://doi.org/10.1016/j.neuron.2021.12.009
State	Published - 5 Jan 2022
Externally published	Yes

Keywords

CH
CSF
NSC
brain ventricle
cerebrospinal fluid
congenital hydrocephalus
genomics
neural development
neural stem cell
neurodevelopmental disorders

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10.1016/j.neuron.2021.12.009

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title = "Brain ventricles as windows into brain development and disease",

abstract = "Dilation of the fluid-filled cerebral ventricles (ventriculomegaly) characterizes hydrocephalus and is frequently seen in autism and schizophrenia. Recent work suggests that the genomic study of congenital hydrocephalus may be unexpectedly fertile ground for revealing insights into neural stem cell regulation, human cerebrocortical development, and pathogenesis of neuropsychiatric disease.",

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AU - Duy, Phan Q.

AU - Rakic, Pasko

AU - Alper, Seth L.

AU - Butler, William E.

AU - Walsh, Christopher A.

AU - Sestan, Nenad

AU - Geschwind, Daniel H.

AU - Jin, Sheng Chih

AU - Kahle, Kristopher T.

PY - 2022/1/5

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AB - Dilation of the fluid-filled cerebral ventricles (ventriculomegaly) characterizes hydrocephalus and is frequently seen in autism and schizophrenia. Recent work suggests that the genomic study of congenital hydrocephalus may be unexpectedly fertile ground for revealing insights into neural stem cell regulation, human cerebrocortical development, and pathogenesis of neuropsychiatric disease.

KW - CH

KW - CSF

KW - NSC

KW - brain ventricle

KW - cerebrospinal fluid

KW - congenital hydrocephalus

KW - genomics

KW - neural development

KW - neural stem cell

KW - neurodevelopmental disorders

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VL - 110

SP - 12

EP - 15

JO - Neuron

JF - Neuron

IS - 1

ER -

Brain ventricles as windows into brain development and disease

Abstract

Keywords

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