Brain ventricles as windows into brain development and disease

Phan Q. Duy, Pasko Rakic, Seth L. Alper, William E. Butler, Christopher A. Walsh, Nenad Sestan, Daniel H. Geschwind, Sheng Chih Jin, Kristopher T. Kahle

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Dilation of the fluid-filled cerebral ventricles (ventriculomegaly) characterizes hydrocephalus and is frequently seen in autism and schizophrenia. Recent work suggests that the genomic study of congenital hydrocephalus may be unexpectedly fertile ground for revealing insights into neural stem cell regulation, human cerebrocortical development, and pathogenesis of neuropsychiatric disease.

Original languageEnglish
Pages (from-to)12-15
Number of pages4
Issue number1
StatePublished - 5 Jan 2022
Externally publishedYes


  • CH
  • CSF
  • NSC
  • brain ventricle
  • cerebrospinal fluid
  • congenital hydrocephalus
  • genomics
  • neural development
  • neural stem cell
  • neurodevelopmental disorders


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