Brain uptake indices of guanidine and 4-aminopyridine

Stephen I. Deutsch; William H. Oldendorf; Kenneth L. Davis

doi:10.1016/0024-3205(84)90217-0

Brain uptake indices of guanidine and 4-aminopyridine

Stephen I. Deutsch
, William H. Oldendorf
, Kenneth L. Davis

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A deficiency of central neural transmission mediated by acetylcholine (ACh) is implicated in the etiopathology of Alzheimer's disease. The appreciation of this neurochemical deficit has led to treatment strategies designed to facilitate central cholinergic transmission (1). A major limitation of current clinical studies is the availability of centrally-effective, long-acting cholinomimetic agents. This situation has led to the search for such agents.

Original language	English
Pages (from-to)	2279-2280
Number of pages	2
Journal	Life Sciences
Volume	34
Issue number	23
DOIs	https://doi.org/10.1016/0024-3205(84)90217-0
State	Published - 4 Jun 1984
Externally published	Yes

Access to Document

10.1016/0024-3205(84)90217-0

Cite this

@article{2869dd58bde74ee0be99a38b7104e53a,

title = "Brain uptake indices of guanidine and 4-aminopyridine",

abstract = "A deficiency of central neural transmission mediated by acetylcholine (ACh) is implicated in the etiopathology of Alzheimer's disease. The appreciation of this neurochemical deficit has led to treatment strategies designed to facilitate central cholinergic transmission (1). A major limitation of current clinical studies is the availability of centrally-effective, long-acting cholinomimetic agents. This situation has led to the search for such agents.",

author = "Deutsch, \{Stephen I.\} and Oldendorf, \{William H.\} and Davis, \{Kenneth L.\}",

year = "1984",

month = jun,

day = "4",

doi = "10.1016/0024-3205(84)90217-0",

language = "English",

volume = "34",

pages = "2279--2280",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "23",

}

TY - JOUR

T1 - Brain uptake indices of guanidine and 4-aminopyridine

AU - Deutsch, Stephen I.

AU - Oldendorf, William H.

AU - Davis, Kenneth L.

PY - 1984/6/4

Y1 - 1984/6/4

N2 - A deficiency of central neural transmission mediated by acetylcholine (ACh) is implicated in the etiopathology of Alzheimer's disease. The appreciation of this neurochemical deficit has led to treatment strategies designed to facilitate central cholinergic transmission (1). A major limitation of current clinical studies is the availability of centrally-effective, long-acting cholinomimetic agents. This situation has led to the search for such agents.

AB - A deficiency of central neural transmission mediated by acetylcholine (ACh) is implicated in the etiopathology of Alzheimer's disease. The appreciation of this neurochemical deficit has led to treatment strategies designed to facilitate central cholinergic transmission (1). A major limitation of current clinical studies is the availability of centrally-effective, long-acting cholinomimetic agents. This situation has led to the search for such agents.

UR - https://www.scopus.com/pages/publications/0021359326

U2 - 10.1016/0024-3205(84)90217-0

DO - 10.1016/0024-3205(84)90217-0

M3 - Article

C2 - 6727563

AN - SCOPUS:0021359326

SN - 0024-3205

VL - 34

SP - 2279

EP - 2280

JO - Life Sciences

JF - Life Sciences

IS - 23

ER -

Brain uptake indices of guanidine and 4-aminopyridine

Abstract

Access to Document

Fingerprint

Cite this