TY - JOUR
T1 - Brain putamen volume changes in newly-diagnosed patients with obstructive sleep apnea
AU - Kumar, Rajesh
AU - Farahvar, Salar
AU - Ogren, Jennifer A.
AU - Macey, Paul M.
AU - Thompson, Paul M.
AU - Woo, Mary A.
AU - Yan-Go, Frisca L.
AU - Harper, Ronald M.
N1 - Funding Information:
The authors thank Ms. Rebecca Harper, Mr. Edwin Valladares, and Drs. Rebecca Cross and Stacy Serber for their help with data collection, and Mr. Jose Palomares for his help in table preparation. This research work was supported by the National Institutes of Health R01 HL-113251 .
PY - 2014
Y1 - 2014
N2 - Obstructive sleep apnea (OSA) is accompanied by cognitive, motor, autonomic, learning, and affective abnormalities. The putamen serves several of these functions, especially motor and autonomic behaviors, but whether global and specific sub-regions of that structure are damaged is unclear. We assessed global and regional putamen volumes in 43 recently-diagnosed, treatment-naïve OSA (age, 46.4 ± 8.8 years; 31 male) and 61 control subjects (47.6 ± 8.8 years; 39 male) using high-resolution T1-weighted images collected with a 3.0-Tesla MRI scanner. Global putamen volumes were calculated, and group differences evaluated with independent samples t-tests, as well as with analysis of covariance (covariates; age, gender, and total intracranial volume). Regional differences between groups were visualized with 3D surface morphometry-based group ratio maps. OSA subjects showed significantly higher global putamen volumes, relative to controls. Regional analyses showed putamen areas with increased and decreased tissue volumes in OSA relative to control subjects, including increases in caudal, mid-dorsal, mid-ventral portions, and ventral regions, while areas with decreased volumes appeared in rostral, mid-dorsal, medial-caudal, and mid-ventral sites. Global putamen volumes were significantly higher in the OSA subjects, but local sites showed both higher and lower volumes. The appearance of localized volume alterations points to differential hypoxic or perfusion action on glia and other tissues within the structure, and may reflect a stage in progression of injury in these newly-diagnosed patients toward the overall volume loss found in patients with chronic OSA. The regional changes may underlie some of the specific deficits in motor, autonomic, and neuropsychologic functions in OSA.
AB - Obstructive sleep apnea (OSA) is accompanied by cognitive, motor, autonomic, learning, and affective abnormalities. The putamen serves several of these functions, especially motor and autonomic behaviors, but whether global and specific sub-regions of that structure are damaged is unclear. We assessed global and regional putamen volumes in 43 recently-diagnosed, treatment-naïve OSA (age, 46.4 ± 8.8 years; 31 male) and 61 control subjects (47.6 ± 8.8 years; 39 male) using high-resolution T1-weighted images collected with a 3.0-Tesla MRI scanner. Global putamen volumes were calculated, and group differences evaluated with independent samples t-tests, as well as with analysis of covariance (covariates; age, gender, and total intracranial volume). Regional differences between groups were visualized with 3D surface morphometry-based group ratio maps. OSA subjects showed significantly higher global putamen volumes, relative to controls. Regional analyses showed putamen areas with increased and decreased tissue volumes in OSA relative to control subjects, including increases in caudal, mid-dorsal, mid-ventral portions, and ventral regions, while areas with decreased volumes appeared in rostral, mid-dorsal, medial-caudal, and mid-ventral sites. Global putamen volumes were significantly higher in the OSA subjects, but local sites showed both higher and lower volumes. The appearance of localized volume alterations points to differential hypoxic or perfusion action on glia and other tissues within the structure, and may reflect a stage in progression of injury in these newly-diagnosed patients toward the overall volume loss found in patients with chronic OSA. The regional changes may underlie some of the specific deficits in motor, autonomic, and neuropsychologic functions in OSA.
KW - 3D surface morphometry
KW - Autonomic
KW - Basal ganglia
KW - Cognition
KW - Intermittent hypoxia
KW - Magnetic resonance imaging
KW - Motor
UR - https://www.scopus.com/pages/publications/84894449617
U2 - 10.1016/j.nicl.2014.01.009
DO - 10.1016/j.nicl.2014.01.009
M3 - Article
C2 - 24567910
AN - SCOPUS:84894449617
SN - 2213-1582
VL - 4
SP - 383
EP - 391
JO - NeuroImage: Clinical
JF - NeuroImage: Clinical
ER -