Brain metabolites B1-corrected proton T1 mapping in the rhesus macaque at 3 T

Songtao Liu, Roman Fleysher, Lazar Fleysher, Chan Gyu Joo, Eva Maria Ratai, R. Gilberto González, Oded Gonen

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The accuracy of metabolic quantification in MR spectroscopy is limited by the unknown radiofrequency field and T1. To address both issues in proton (1H) MR spectroscopy, we obtained radiofrequency field-corrected T1 maps of N-acetylaspartate, choline, and creatine in five healthy rhesus macaques at 3 T. For efficient use of the 4 hour experiment, we used a new three-point protocol that optimizes the precision of T1 in three-dimensional 1H-MR spectroscopy localization for extensive, ∼30%, brain coverage at 0.6 × 0.6 × 0.5 cm 3 = 180-μL spatial resolution. The resulting mean T1s in 700 voxels were N-acetylaspartate = 1232 ± 44, creatine = 1238 ± 23 and choline = 1107 ± 56 ms (mean ± standard error of the mean). Their histograms from all 140 voxels in each animal were similar in position and shape, characterized by standard errors of the mean of the full width at half maximum divided by their means of better than 8%. Regional gray matter N- acetylaspartate, choline, and creatine T1s (1333 ± 43, 1265 ± 52, and 1131 ± 28 ms) were 5-10% longer than white matter: 1188 ± 34, 1201 ± 24, and 1082 ± 50 ms (statistically significant for the N-acetylaspartate only), all within 10% of the corresponding published values in the human brain.

Original languageEnglish
Pages (from-to)865-871
Number of pages7
JournalMagnetic Resonance in Medicine
Issue number4
StatePublished - May 2010
Externally publishedYes


  • Brain MR spectroscopy
  • Brain metabolites
  • Longitudinal relaxation time
  • Rhesus macaque


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