Brain-Heart Interaction in Takotsubo Cardiomyopathy

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Takotsubo cardiomyopathy is classically stress induced and characterized by regional wall motion abnormalities in the absence of coronary occlusion. It predominantly affects postmenopausal women; emotional and physical stressors can trigger the classic cardiomyopathic findings. These changes are likely mediated by catecholamines, which cause a distinctive pattern of ventricular dysfunction with a unique pathologic phenotype of apical ballooning. Underlying mood disorders increase the risk for developing takotsubo cardiomyopathy after a triggering event. Takotsubo cardiomyopathy is one of several brain-heart disorders; its unique pathology can shed light on the complex interactions between the brain, sympathetic nervous system, and the cardiovascular system.

Original languageEnglish
Pages (from-to)217-223
Number of pages7
JournalHeart Failure Clinics
Issue number2
StatePublished - Apr 2013


  • Apical ballooning syndrome
  • Stress cardiomyopathy
  • Sympathetic activation
  • Takotsubo cardiomyopathy


Dive into the research topics of 'Brain-Heart Interaction in Takotsubo Cardiomyopathy'. Together they form a unique fingerprint.

Cite this