TY - JOUR
T1 - Brain Glucose Metabolism in Neurologically Normal Patients With Sickle Cell Disease
T2 - Regional Alterations
AU - Rodgers, Griffin P.
AU - Clark, Campbell M.
AU - Larson, Steven M.
AU - Rapoport, Stanley I.
AU - Nienhuis, Arthur W.
AU - Schechter, Alan N.
PY - 1988/1
Y1 - 1988/1
N2 - Neurologic dysfunction is a significant source of morbidity and mortality in the sickle cell diseases, occurring with a prevalence of 6% to 34%. Because changes in brain glucose metabolism may precede gross functional or morphologic alterations, we recently applied the technique of positron emission tomography with fluorodeoxyglucose F 18 in an exploratory study to compare six patients with sickle cell disease without prior neurologic abnormalities (and with normal cranial computed tomographic scans) with six healthy age-matched controls, with respect to overall and regional cerebral metabolic rates for glucose. We found no significant difference in the global metabolic rates for the two groups. However, we observed an unusual clustering of abnormal regional cerebral metabolic rates for glucose in the frontal lobes of these subjects. These results support previous observations that frontal lobe involvement may be quite prevalent in sickle cell disease, even among individuals with normal computed tomographic scans.
AB - Neurologic dysfunction is a significant source of morbidity and mortality in the sickle cell diseases, occurring with a prevalence of 6% to 34%. Because changes in brain glucose metabolism may precede gross functional or morphologic alterations, we recently applied the technique of positron emission tomography with fluorodeoxyglucose F 18 in an exploratory study to compare six patients with sickle cell disease without prior neurologic abnormalities (and with normal cranial computed tomographic scans) with six healthy age-matched controls, with respect to overall and regional cerebral metabolic rates for glucose. We found no significant difference in the global metabolic rates for the two groups. However, we observed an unusual clustering of abnormal regional cerebral metabolic rates for glucose in the frontal lobes of these subjects. These results support previous observations that frontal lobe involvement may be quite prevalent in sickle cell disease, even among individuals with normal computed tomographic scans.
UR - http://www.scopus.com/inward/record.url?scp=0023839937&partnerID=8YFLogxK
U2 - 10.1001/archneur.1988.00520250084025
DO - 10.1001/archneur.1988.00520250084025
M3 - Article
C2 - 3257387
AN - SCOPUS:0023839937
SN - 0003-9942
VL - 45
SP - 78
EP - 82
JO - Archives of Neurology
JF - Archives of Neurology
IS - 1
ER -