Brain DA D2 receptors predict reinforcing effects of stimulants in humans: Replication study

Nora D. Volkow, Gene Jack Wang, Joanna S. Fowler, Pether Thanos, Jean Logan, Samuel J. Gatley, Andrew Gifford, Yu Shin Ding, Chris Wong, Naomi Pappas

Research output: Contribution to journalArticlepeer-review

224 Scopus citations

Abstract

We had shown that striatal DA D2 receptors levels predicted the reinforcing responses to the psychostimulant drug methylphenidate in nondrug-abusing subjects. Here, we assessed the replicability of this finding. We measured D2 receptors with PET and [11C]raclopride (twice to determine stability) in seven nondrug-abusing subjects to assess if they predicted the self-reports of "drug-liking" to intravenous methylphenidate (0.5 mg/kg). DA D2 measures were significantly correlated with "drug-liking" in both evaluations (r = 0.82 and r = 0.78); subjects with the lowest levels reported the higher ratings of "drug-liking" and vice versa. These results replicate our previous findings and provide further evidence that striatal DA D2 receptors modulate reinforcing responses to stimulants in humans and may underlie predisposition for drug self-administration.

Original languageEnglish
Pages (from-to)79-82
Number of pages4
JournalSynapse
Volume46
Issue number2
DOIs
StatePublished - Nov 2002
Externally publishedYes

Keywords

  • Addiction
  • Methylphenidate
  • PET
  • Raclopride
  • Reinforcemnt
  • Striatum
  • Vulnerability

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