Brain and behavior changes during sleep deprivation

M. Thomas, H. Sing, G. Belenky, H. Holcomb, H. Mayberg, R. Dannals, H. Wagner, D. Thorne, K. Popp, L. Rowland, A. Welsh, D. Redmond

Research output: Contribution to journalConference articlepeer-review

2 Scopus citations


An experiment was conducted to demonstrate the degradation on cognitive performance and its brain correlates during sleep deprivation. The study used positron emission tomography (PET), a brain imaging technique, and 2-[18F]fluoro-2-deoxy-D-glucose (FDG), an index of regional cerebral glucose metabolic rate (rCMRglu) and brain activity. Twenty-four hours of sleep deprivation resulted in decreased alertness and cognitive performance, and in decreased rCMRglu, predominantly in prefrontal and posterior parietal cortices, and thalamus. These results provide evidence that the impairments produced by sleep deprivation have a biological basis in reduced brain activity in regions subserving higher-order cognitive and alertness functions.

Original languageEnglish
Pages (from-to)1608
Number of pages1
JournalProceedings of the Human Factors and Ergonomics Society
StatePublished - 1998
Externally publishedYes
EventProceedings of the 1998 42nd Annual Meeting 'Human Factors and Ergonomics Society' - Chicago, IL, USA
Duration: 5 Oct 19989 Oct 1998


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