Brain abscess

D. P. Calfee, B. Wispelwey

Research output: Contribution to journalReview articlepeer-review

91 Scopus citations


The epidemiology of brain abscess has changed with the increasing incidence of this infection in immunocompromised patients, particularly solid organ and bone marrow transplant recipients, and the decreasing incidence of brain abscess related to sinusitis and otitis. A number of new neuroimaging modalities, including single photon emission computed tomography, positron emission tomography, perfusion magnetic resonance imaging, and magnetic resonance spectroscopy, provide an initial noninvasive approach to diagnosis. The recommendations for the management of intracranial mass lesions in human immunodeficiency virus-infected individuals has changed as the incidence of toxoplasmic encephalitis has decreased with the use of trimethoprim-sulfamethoxazole prophylaxis. The epidemiology, pathogenesis, microbiology, clinical presentation, diagnosis, treatment and prognosis of brain abscess in the beginning of the 21st century are provided in this review.

Original languageEnglish
Pages (from-to)353-360
Number of pages8
JournalSeminars in Neurology
Issue number3
StatePublished - 2000
Externally publishedYes


  • Abscess
  • Central nervous system
  • Immunosuppression


Dive into the research topics of 'Brain abscess'. Together they form a unique fingerprint.

Cite this