Botulinum toxin treatment of facial myoclonus in suspected Rasmussen encephalitis

Nina Browner, Shaheda N. Azher, Joseph Jankovic

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Patients with Rasmussen encephalitis (RE) may develop a variety of involuntary movements. We report a 26-year-old woman who presented with a 3-year history of progressive, continuous myoclonus of the left side of the face and left arm as well as left spastic hemiparesis. Magnetic resonance imaging of the brain showed right hemisphere and basal ganglia atrophy, and 24-hour electroencephalogram demonstrated diffuse slowing with random sharp waves in both hemispheres. An 18-fluoro-deoxy-glucose positron emission tomography scan indicated hypometabolism of the right cerebral hemisphere, including basal ganglia and thalamus. We successfully treated her myoclonus with injections of botulinum toxin A into the left zygomaticus muscle.

Original languageEnglish
Pages (from-to)1500-1502
Number of pages3
JournalMovement Disorders
Issue number9
StatePublished - Sep 2006
Externally publishedYes


  • Botulinum toxin
  • Myoclonus
  • Rasmussen encephalitis


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