Bosniak IIF and III renal cysts: Can apparent diffusion coefficient-derived texture features discriminate between malignant and benign IIF and III cysts?

Nicolas Gillingham, Hersh Chandarana, Amita Kamath, Hiram Shaish, Nicole Hindman

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Objective: The aim of this study was to determine which apparent diffusion coefficient-derived texture features are associated with malignancy in Bosniak IIF and III renal cystic lesions. Methods: Twenty benign and 7 malignant Bosniak IIF (22) or III (5) renal cysts, as evaluated with magnetic resonance imaging, were assessed for progression to pathology-confirmed malignancy. Whole-cyst volumes of interest were manually segmented from apparent diffusion coefficient maps. Texture features were extracted from each volume of interest, including first-order histogram-based features and higher-order features, and data were analyzed with the Mann-Whitney U test to predict malignant progression. Results: Eleven of 17 first-order features were significantly greater in benign compared with malignant cysts. Eight higher-order gray-level co-occurrence matrix (GLCM) texture features were significantly different between groups, 5 of which were greater in the benign population. Conclusions: Apparent diffusion coefficient-derived texture measures may help differentiate between benign and malignant Bosniak IIF and III cysts.

Original languageEnglish
Pages (from-to)485-492
Number of pages8
JournalJournal of Computer Assisted Tomography
Volume43
Issue number3
DOIs
StatePublished - 2019

Keywords

  • Diffusion-weighted imaging
  • MRI
  • Radiomics
  • Renal cysts
  • Texture analysis

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