TY - JOUR
T1 - Bone tropism in cancer metastases
AU - Wang, Hai
AU - Zhang, Weijie
AU - Bado, Igor
AU - Zhang, Xiang H.F.
N1 - Funding Information:
We apologize to the individuals whose contribution to bone metastasis research was not discussed and cited in this review due to limitations in space and scope. X.H.-F.Z. is supported by the U.S. Department of Defense DAMD W81XWH-16-1-0073, NCI CA183878, and CA221946, the Breast Cancer Research Foundation, and the McNair Medical Institute. H.W. is supported in part by the US Department of Defense DAMD W81XWH-13-1-0296.
Publisher Copyright:
© 2020 Cold Spring Harbor Laboratory Press; all rights reserved.
PY - 2020
Y1 - 2020
N2 - Bone is a frequent site of metastases in many cancers. Both bone properties and the tumorintrinsic traits are associated with the metastatic propensity to bone (i.e., the bone tropism). Whereas an increasing body of mechanistic studies expanded our understanding on bone tropism, they also revealed complexity across the bone lesions originated from different cancer types. In this review, we will discuss the physical, chemical, and biological properties of bone microenvironment, identify potential players in every stage of bone metastases, and introduce some of the known mechanisms regulating the bone colonization. Our objectives are to integrate the knowledge established in different biological contexts and highlight the determinants of bone tropism.
AB - Bone is a frequent site of metastases in many cancers. Both bone properties and the tumorintrinsic traits are associated with the metastatic propensity to bone (i.e., the bone tropism). Whereas an increasing body of mechanistic studies expanded our understanding on bone tropism, they also revealed complexity across the bone lesions originated from different cancer types. In this review, we will discuss the physical, chemical, and biological properties of bone microenvironment, identify potential players in every stage of bone metastases, and introduce some of the known mechanisms regulating the bone colonization. Our objectives are to integrate the knowledge established in different biological contexts and highlight the determinants of bone tropism.
UR - http://www.scopus.com/inward/record.url?scp=85091941798&partnerID=8YFLogxK
U2 - 10.1101/cshperspect.a036848
DO - 10.1101/cshperspect.a036848
M3 - Article
C2 - 31615871
AN - SCOPUS:85091941798
VL - 10
SP - 1
EP - 17
JO - Cold Spring Harbor Perspectives in Medicine
JF - Cold Spring Harbor Perspectives in Medicine
SN - 2157-1422
IS - 10
M1 - a036848
ER -