Bone morphogenetic proteins in vertebrate hematopoietic development

Alexandra Snyder, Stuart T. Fraser, Margaret H. Baron

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

During embryonic development, the hematopoietic system is the first to generate terminally differentiated, functional cell types. The urgent necessity for the early formation of blood and blood vessels during embryogenesis means that the induction, expansion, and maturation of these systems must be rapidly and precisely controlled. Bone morphogenic proteins (BMPs) have been implicated in hematopoietic development in the vertebrate embryo and stimulate the proliferation and/or differentiation of human cord blood hematopoietic stem cells (HSC) and embryonic stem cells in vitro. Here we review the mechanisms of action and potential roles of these soluble signaling molecules in vertebrate hematopoiesis.

Original languageEnglish
Pages (from-to)224-232
Number of pages9
JournalJournal of Cellular Biochemistry
Volume93
Issue number2
DOIs
StatePublished - 2004

Keywords

  • Bone morphogenetic protein
  • Hematopoiesis
  • Morphogens
  • Signaling molecules
  • Stem cell

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