Bone mineral density and skeletal outcomes in congenital adrenal hyperplasia

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Congenital adrenal hyperplasia (CAH) is an autosomal recessive group of disorders characterized by cortisol deficiency and excessive production of adrenal androgens due to impaired cortisol synthesis. Cortisol deficiency usually requires life-long therapy with glucocorticoids (GCs). In other disease states, chronic GC therapy has been associated with decreased bone mineral density (BMD) and osteoporosis. However, BMD data in individuals with CAH are conflicting. In this chapter, we review the effects of GCs and sex steroids on bone metabolism and discuss the data available to-date regarding skeletal outcomes in individuals with CAH.

Original languageEnglish
Title of host publicationGenetic Steroid Disorders
Subtitle of host publicationSecond Edition
PublisherElsevier
Pages169-177
Number of pages9
ISBN (Electronic)9780128214244
ISBN (Print)9780128214251
DOIs
StatePublished - 1 Jan 2023

Keywords

  • Bone mineral density
  • DXA
  • adrenal hormones
  • androgens
  • estrogens
  • fracture
  • glucocorticoids
  • sex steroids

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