TY - JOUR
T1 - Bone marrow metastases from glioblastoma multiforme - A case report and review of the literature
AU - Rajagopalan, Vandana
AU - El Kamar, Francois G.
AU - Thayaparan, Rose
AU - Grossbard, Michael L.
PY - 2005/4
Y1 - 2005/4
N2 - Clinically detected extra-cranial metastases from glioblastoma multiforme (GBM) are quite rare, with an incidence of <2% reported in the published literature. Among the various reported sites of systemic metastases from GBM, there are few cases of clinically symptomatic bone marrow metastasis. The case of a patient developing systemic dissemination of a GBM is described. A 60-year-old man with GBM who developed back pain, thrombocytopenia and subsequently neurological deficits was found to have extensive bony and bone marrow metastases. Previously reported cases of extra-cranial systemic spread of GBM and attempts made in the literature to explain the possible routes of extra-neural dissemination are reviewed.
AB - Clinically detected extra-cranial metastases from glioblastoma multiforme (GBM) are quite rare, with an incidence of <2% reported in the published literature. Among the various reported sites of systemic metastases from GBM, there are few cases of clinically symptomatic bone marrow metastasis. The case of a patient developing systemic dissemination of a GBM is described. A 60-year-old man with GBM who developed back pain, thrombocytopenia and subsequently neurological deficits was found to have extensive bony and bone marrow metastases. Previously reported cases of extra-cranial systemic spread of GBM and attempts made in the literature to explain the possible routes of extra-neural dissemination are reviewed.
KW - Anemia
KW - Bone marrow metastases
KW - Bone metastases
KW - Glioblastoma multiforme
KW - thrombocytopenia
UR - http://www.scopus.com/inward/record.url?scp=20444404991&partnerID=8YFLogxK
U2 - 10.1007/s11060-004-3346-y
DO - 10.1007/s11060-004-3346-y
M3 - Article
C2 - 15925996
AN - SCOPUS:20444404991
SN - 0167-594X
VL - 72
SP - 157
EP - 161
JO - Journal of Neuro-Oncology
JF - Journal of Neuro-Oncology
IS - 2
ER -