Bone marrow metastases from glioblastoma multiforme - A case report and review of the literature

Vandana Rajagopalan, Francois G. El Kamar, Rose Thayaparan, Michael L. Grossbard

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48 Scopus citations

Abstract

Clinically detected extra-cranial metastases from glioblastoma multiforme (GBM) are quite rare, with an incidence of <2% reported in the published literature. Among the various reported sites of systemic metastases from GBM, there are few cases of clinically symptomatic bone marrow metastasis. The case of a patient developing systemic dissemination of a GBM is described. A 60-year-old man with GBM who developed back pain, thrombocytopenia and subsequently neurological deficits was found to have extensive bony and bone marrow metastases. Previously reported cases of extra-cranial systemic spread of GBM and attempts made in the literature to explain the possible routes of extra-neural dissemination are reviewed.

Original languageEnglish
Pages (from-to)157-161
Number of pages5
JournalJournal of Neuro-Oncology
Volume72
Issue number2
DOIs
StatePublished - Apr 2005
Externally publishedYes

Keywords

  • Anemia
  • Bone marrow metastases
  • Bone metastases
  • Glioblastoma multiforme
  • thrombocytopenia

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